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His1:CG33855 histone H1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3771991, updated on 9-Dec-2024

Summary

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Official Symbol
His1:CG33855provided by FlyBase
Official Full Name
histone H1provided by FlyBase
Primary source
FLYBASE:FBgn0053855
Locus tag
Dmel_CG33855
See related
AllianceGenome:FB:FBgn0053855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33855; Dmel\CG33855
Summary
Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation and negative regulation of DNA recombination. Predicted to be located in chromatin. Predicted to be part of nucleosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See His1:CG33855 in Genome Data Viewer
Location:
39E1-39E1; 2-54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21521616..21522638)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21521616..21522638)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene histone H4 Neighboring gene histone H3 Neighboring gene histone H2B Neighboring gene histone H2A Neighboring gene small non-coding RNA 430q

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation. Cugusi S, et al. Mol Cell Proteomics, 2015 Jun. PMID 25776889, Free PMC Article
  2. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273
  3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  4. The Release 6 reference sequence of the Drosophila melanogaster genome. Hoskins RA, et al. Genome Res, 2015 Mar. PMID 25589440, Free PMC Article
  5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histone H1
Names
CG33855-PA
His1:CG33855-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21521616..21522638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032198.2 → NP_001027369.1  histone H1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027369.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4AB54, Q5BI49
    Conserved Domains (1) summary
    pfam00538
    Location:46 → 118
    Linker_histone; linker histone H1 and H5 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4AB54 Q4AB54

Gene LinkOut

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Molecular Biology Databases
Research Materials