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kay kayak [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3772082, updated on 9-Dec-2024

Summary

Official Symbol
kayprovided by FlyBase
Official Full Name
kayakprovided by FlyBase
Primary source
FLYBASE:FBgn0001297
Locus tag
Dmel_CG33956
See related
AllianceGenome:FB:FBgn0001297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AP-1; Ap1; AP1; c-fos; c-Fos; CG15507; CG15509; CG33956; d-fos; d-Fos; D-fos; D-Fos; D-fos/kay; dAP-1; dfos; dFos; Dfos; DFos; DFOS; dFra; dFRA; DFra; dlhD; DM3; DM30; Dmel\CG33956; fbz; fos; Fos; FOS; fra; Fra; Kay; KAY
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including imaginal disc fusion, thorax closure; locomotor rhythm; and nervous system development. Acts upstream of with a positive effect on G2/M transition of mitotic cell cycle and second mitotic wave involved in compound eye morphogenesis. Located in cytoplasm and nucleus. Part of transcription factor AP-1 complex. Is expressed in several structures, including epithelial cell; epithelium; gut section; motor neurons; and sensory neurons. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit); FOSL2 (FOS like 2, AP-1 transcription factor subunit); and FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See kay in Genome Data Viewer
Location:
99B10-99C1; 3-99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29765995..29794113)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25591717..25619835)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44953 Neighboring gene yata Neighboring gene long non-coding RNA:CR46110 Neighboring gene fos intronic gene Neighboring gene shroud Neighboring gene R and B Neighboring gene Death related ICE-like caspase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
acts_upstream_of_positive_effect G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in R3/R4 cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collateral sprouting of injured axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in follicle cell of egg chamber migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc fusion, thorax closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidoglycan recognition protein signaling pathway HMP PubMed 
involved_in peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria HMP PubMed 
involved_in positive regulation of border follicle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_positive_effect second mitotic wave involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor AP-1 complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
kayak
Names
CG33956-PA
CG33956-PB
CG33956-PD
CG33956-PF
CG33956-PG
Dfos/kayak
Fos
Fos-related antigen
activator protein 1
dorsal holes D
kay-PA
kay-PB
kay-PD
kay-PF
kay-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29765995..29794113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032408.3NP_001027580.1  kayak, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MPH8, A8MPH9
    Conserved Domains (1) summary
    cd14721
    Location:387448
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
  2. NM_001300662.1NP_001287591.1  kayak, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHU8
    Conserved Domains (1) summary
    cd14721
    Location:311372
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
  3. NM_001032407.3NP_001027579.1  kayak, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027579.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4JC86
    Conserved Domains (1) summary
    cd14721
    Location:260321
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
  4. NM_001032406.2NP_001027578.1  kayak, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027578.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21525
    Conserved Domains (1) summary
    cd14721
    Location:211272
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
  5. NM_001032405.4NP_001027577.2  kayak, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027577.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MPI0, P21525, Q400M6, Q400M7, Q53YJ8, Q8T9E2, Q9BH37, Q9NBW7, Q9VAH5
    Conserved Domains (1) summary
    cd14721
    Location:420481
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain