kay - kayak

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including imaginal disc fusion, thorax closure; locomotor rhythm; and nervous system development. Acts upstream of with a positive effect on G2/M transition of mitotic cell cycle and second mitotic wave involved in compound eye morphogenesis. Located in cytoplasm and nucleus. Part of transcription factor AP-1 complex. Is expressed in several structures, including epithelial cell; epithelium; gut section; motor neurons; and sensory neurons. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit); FOSL2 (FOS like 2, AP-1 transcription factor subunit); and FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Nov 2024]

NCBI Orthologs

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