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His4:CG33879 histone H4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3772319, updated on 9-Dec-2024

Summary

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Official Symbol
His4:CG33879provided by FlyBase
Official Full Name
histone H4provided by FlyBase
Primary source
FLYBASE:FBgn0053879
Locus tag
Dmel_CG33879
See related
AllianceGenome:FB:FBgn0053879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33879; Dmel\CG33879
Summary
Enables DNA binding activity. Involved in nucleosome assembly. Located in nuclear chromosome. Part of RCAF complex and nucleosome. Orthologous to several human genes including H4C1 (H4 clustered histone 1); H4C11 (H4 clustered histone 11); and H4C12 (H4 clustered histone 12). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See His4:CG33879 in Genome Data Viewer
Location:
39D5-39D5; 2-54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21509422..21509834, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21509422..21509834, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene histone H2B Neighboring gene histone H2A Neighboring gene small non-coding RNA 430n Neighboring gene histone H3 Neighboring gene histone H1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the Drosophila histone H4 replacement gene. Akhmanova A, et al. FEBS Lett, 1996 Jun 17. PMID 8690091
  2. Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila. Bone JR, et al. Genes Dev, 1994 Jan. PMID 8288132
  3. Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions. Figueiredo ML, et al. PLoS Genet, 2014 Dec. PMID 25501352, Free PMC Article
  4. The RCAF complex mediates chromatin assembly during DNA replication and repair. Tyler JK, et al. Nature, 1999 Dec 2. PMID 10591219
  5. The Release 6 reference sequence of the Drosophila melanogaster genome. Hoskins RA, et al. Genome Res, 2015 Mar. PMID 25589440, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RCAF complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
histone H4
Names
CG33879-PA
His4:CG33879-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21509422..21509834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032186.2 → NP_001027357.1  histone H4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027357.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P84040
    Conserved Domains (2) summary
    PLN00035
    Location:1 → 103
    PLN00035; histone H4; Provisional
    cd00076
    Location:18 → 101
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84040.2 P84040

Gene LinkOut

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