Chrac-14 Chromatin accessibility complex 14kD protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Chrac-14provided by FlyBase
Official Full Name: Chromatin accessibility complex 14kD proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0043002
Locus tag: Dmel_CG13399
See related: AllianceGenome:FB:FBgn0043002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 13399; 18K protein; 55A11T; CG13399; CG32956; CHRAC; chrac-14; CHRAC-14; Chrac14; CHRAC14; dChrac14; Dmel\CG13399; ESTS:55A11T; mary; PolE3
Summary: Predicted to enable chromatin DNA binding activity. Involved in CENP-A containing chromatin assembly; DNA damage response; and cellular response to gamma radiation. Part of ATAC complex and CHRAC. Is expressed in several structures, including antennal anlage; antennal primordium; anterior endoderm; anterior endoderm anlage; and head epidermis primordium. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8437405..8437996)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8437405..8437996)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

CHRAC14 modulates chromatin composition in response to DNA damage.
Title: The histone-fold protein CHRAC14 influences chromatin composition in response to DNA damage.
X-ray crystallographic structure of Drosophila melanogaster CHRAC14-CHRAC16 dimer
Title: The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CENP-A containing chromatin assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in CENP-A containing chromatin assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	IPI Inferred from Physical Interaction more info	PubMed
part_of CHRAC	IBA Inferred from Biological aspect of Ancestor more info
part_of CHRAC	IDA Inferred from Direct Assay more info	PubMed
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain