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mei-218 meiotic 218 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3772646, updated on 4-Jan-2025

Summary

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Official Symbol
mei-218provided by FlyBase
Official Full Name
meiotic 218provided by FlyBase
Primary source
FLYBASE:FBgn0002709
Locus tag
Dmel_CG8923
See related
AllianceGenome:FB:FBgn0002709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33067; CG8923; Dmel\CG8923; Mei-218
Summary
Involved in female meiosis chromosome segregation and reciprocal meiotic recombination. Located in cytoplasm. Is expressed in organism. Orthologous to human MCMDC2 (minichromosome maintenance domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mei-218 in Genome Data Viewer
Location:
15E5-15E5; 1-57 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17135985..17142990, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17030018..17037029, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 2/3 complex, subunit 3B Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene meiotic 217 Neighboring gene Ribosomal protein S5a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Are there morphologically abnormal early recombination nodules in the Drosophila melanogaster meiotic mutant mei-218? Carpenter AT. Genome, 1989. PMID 2512198
  2. Meiotic roles of crossing-over and of gene conversion. Carpenter AT. Cold Spring Harb Symp Quant Biol, 1984. PMID 6597757
  3. Induction of metaphase arrest in Drosophila oocytes by chiasma-based kinetochore tension. Jang JK, et al. Science, 1995 Jun 30. PMID 7604267
  4. The effect of recombination-defective meiotic mutants on fourth-chromosome crossing over in Drosophila melanogaster. Sandler L, et al. Genetics, 1978 Dec. PMID 105965, Free PMC Article
  5. The effects of recombination-defective meiotic mutants in Drosophila melanogaster on gonial recombination in males. Lutken T, et al. Mutat Res, 1979 Jul. PMID 113674

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long, disordered N-terminus of MEI-218 is dispensable for crossover formation.
    Title: Meiotic MCM Proteins Promote and Inhibit Crossovers During Meiotic Recombination.
  2. Intragenic recombination experiments suggest that mei-218 is required for a molecular transition of the recombination intermediate late in the double strand break repair pathway
    Title: Studies on crossover-specific mutants and the distribution of crossing over in Drosophila females.
  3. MEI-218 is a protein required for meiotic crossing-over in Drosophila.
    Title: Cytoplasmic localization and evolutionary conservation of MEI-218, a protein required for meiotic crossing-over in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c17137633-17137594 mobile_element_type = transposon:Q{}4224

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
meiotic 218
Names
CG8923-PB
CG8923-PC
CG8923-PD
CG8923-PE
mei-218-PB
mei-218-PC
mei-218-PD
mei-218-PE
transcript c

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17135985..17142990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144743.2 → NP_001138215.1  meiotic 218, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138215.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHR4, Q24137
    Conserved Domains (2) summary
    PTZ00112
    Location:122 → 417
    PTZ00112; origin recognition complex 1 protein; Provisional
    pfam00493
    Location:1023 → 1116
    MCM; MCM2/3/5 family

  2. NM_001031897.3 → NP_001027068.1  meiotic 218, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHR4, Q24137
    Conserved Domains (2) summary
    PTZ00112
    Location:122 → 417
    PTZ00112; origin recognition complex 1 protein; Provisional
    pfam00493
    Location:1023 → 1116
    MCM; MCM2/3/5 family

  3. NM_001201728.1 → NP_001188657.1  meiotic 218, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188657.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHR4, Q24137
    Conserved Domains (2) summary
    PTZ00112
    Location:122 → 417
    PTZ00112; origin recognition complex 1 protein; Provisional
    pfam00493
    Location:1023 → 1116
    MCM; MCM2/3/5 family

  4. NM_167557.3 → NP_728052.2  meiotic 218, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728052.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHR4, Q24137
    Conserved Domains (2) summary
    PTZ00112
    Location:122 → 417
    PTZ00112; origin recognition complex 1 protein; Provisional
    pfam00493
    Location:1023 → 1116
    MCM; MCM2/3/5 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KHR4 Q0KHR4
Q24137 Q24137
Q8MR81 Q8MR81

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