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levy levy [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37728, updated on 4-Jan-2025

Summary

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Official Symbol
levyprovided by FlyBase
Official Full Name
levyprovided by FlyBase
Primary source
FLYBASE:FBgn0034877
Locus tag
Dmel_CG17280
See related
AllianceGenome:FB:FBgn0034877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH03295; CG17280; Cox6a; COX6A; COXD; COXE; Dmel\CG17280; Levy; VIa
Summary
Enables enzyme regulator activity. Involved in determination of adult lifespan and mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut; and embryonic/larval midgut primordium. Used to study cytochrome-c oxidase deficiency disease and mitochondrial encephalomyopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D and mitochondrial complex IV deficiency nuclear type 18. Orthologous to several human genes including COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See levy in Genome Data Viewer
Location:
59E3-59E3; 2-103 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23548239..23548982)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19435762..19436505)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 59f Neighboring gene aaRS-interacting multifunctional protein 3 Neighboring gene wing morphogenesis defect Neighboring gene pita Neighboring gene Death caspase-1 Neighboring gene Rrp4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies. Graham C, et al. Geroscience, 2022 Aug. PMID 35355221, Free PMC Article
  2. Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. Liu W, et al. Genetics, 2007 Jun. PMID 17435251, Free PMC Article
  3. Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections. Brown AE, et al. PLoS One, 2009. PMID 19221590, Free PMC Article
  4. Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (Drosophila melanogaster) to Ether and Non-Ether Volatile Anesthetics. Borchardt LA, et al. Int J Mol Sci, 2023 Jan 17. PMID 36768163, Free PMC Article
  5. Sequence elements in cis influence heterochromatic silencing in trans. Sage BT, et al. Mol Cell Biol, 2005 Jan. PMID 15601858, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IC
Inferred by Curator
more info
 PubMed 
part_of respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
levy
Names
CG17280-PA
CG17280-PB
cytochrome c oxidase VIa
cytochrome c oxidase polypeptide VIA
cytochrome c oxidase subunit 6A
levy-PA
levy-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23548239..23548982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137961.3 → NP_611805.1  levy, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1N3
    Related
    FBpp0071970
    Conserved Domains (1) summary
    cd00925
    Location:24 → 108
    Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_001299841.1 → NP_001286770.1  levy, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286770.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1N3
    Conserved Domains (1) summary
    cd00925
    Location:24 → 108
    Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1N3 Q9W1N3

Gene LinkOut

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