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Pde8 - Phosphodiesterase 8

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in mesoderm development and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including adult fat body; adult head; embryonic anal pad; gut section; and salivary gland body primordium. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8A (phosphodiesterase 8A) and PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Pde8

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Species Gene Architecture aa