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Pde8 Phosphodiesterase 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37741, updated on 9-Dec-2024

Summary

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Official Symbol
Pde8provided by FlyBase
Official Full Name
Phosphodiesterase 8provided by FlyBase
Primary source
FLYBASE:FBgn0266377
Locus tag
Dmel_CG45019
See related
AllianceGenome:FB:FBgn0266377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG42241; CG45019; CG5411; Dmel\CG45019; pde8; PDE8
Old locus tag
Dmel_CG42241; Dmel_CG5411
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in mesoderm development and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including adult fat body; adult head; embryonic anal pad; gut section; and salivary gland body primordium. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8A (phosphodiesterase 8A) and PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pde8 in Genome Data Viewer
Location:
59F5-59F6; 2-104 cM
Exon count:
26
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23657567..23680844)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19545090..19568367)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Entomoglyceroporin 2 Neighboring gene Entomoglyceroporin 4 Neighboring gene long non-coding RNA:CR45153 Neighboring gene retained Neighboring gene lethal (2) essential for life Neighboring gene Sulfotransferase 1 Neighboring gene Sulfotransferase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. Choi C, et al. Cell Rep, 2012 Aug 30. PMID 22938867, Free PMC Article
  2. Translation of CircRNAs. Pamudurti NR, et al. Mol Cell, 2017 Apr 6. PMID 28344080, Free PMC Article
  3. Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Day JP, et al. Biochem J, 2005 May 15. PMID 15673286, Free PMC Article
  4. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Brown KM, et al. Proc Natl Acad Sci U S A, 2013 Apr 16. PMID 23509299, Free PMC Article
  5. White - cGMP Interaction Promotes Fast Locomotor Recovery from Anoxia in Adult Drosophila. Xiao C, et al. PLoS One, 2017. PMID 28060942, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP metabolic process ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphodiesterase 8
Names
CG45019-PA
CG45019-PB
CG45019-PC
CG45019-PD
CG45019-PE
CG45019-PI
CG45019-PK
CG45019-PN
CG45019-PO
CG45019-PP
CG45019-PQ
CG45019-PR
Pde8-PA
Pde8-PB
Pde8-PC
Pde8-PD
Pde8-PE
Pde8-PI
Pde8-PK
Pde8-PN
Pde8-PO
Pde8-PP
Pde8-PQ
Pde8-PR
NP_001163274.1
NP_001163275.2
NP_001163276.1
NP_001163278.2
NP_001400989.1
NP_001401020.1
NP_001401021.1
NP_611814.3
NP_726350.1
NP_726351.1
NP_726352.1
NP_726353.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23657567..23680844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166616.3 → NP_726350.1  phosphodiesterase 8, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726350.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
    Related
    FBpp0310592
    Conserved Domains (2) summary
    pfam00233
    Location:639 → 871
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:327 → 403
    PAS_9; PAS domain

  2. NM_001169807.2 → NP_001163278.2  phosphodiesterase 8, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163278.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGU6
    Conserved Domains (3) summary
    cd00130
    Location:323 → 403
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:639 → 880
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:327 → 403
    PAS_9; PAS domain

  3. NM_137970.5 → NP_611814.3  phosphodiesterase 8, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611814.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NNF2
    Conserved Domains (2) summary
    pfam00233
    Location:630 → 862
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:327 → 403
    PAS_9; PAS domain

  4. NM_001169803.2 → NP_001163274.1  phosphodiesterase 8, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
    Conserved Domains (2) summary
    pfam00233
    Location:639 → 871
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:327 → 403
    PAS_9; PAS domain

  5. NM_001414110.1 → NP_001400989.1  phosphodiesterase 8, isoform P [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PDF0

  6. NM_001169805.2 → NP_001163276.1  phosphodiesterase 8, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163276.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
    Conserved Domains (2) summary
    pfam00233
    Location:639 → 871
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:327 → 403
    PAS_9; PAS domain

  7. NM_001414112.1 → NP_001401021.1  phosphodiesterase 8, isoform R [Drosophila melanogaster]

    Status: REVIEWED

  8. NM_001414111.1 → NP_001401020.1  phosphodiesterase 8, isoform Q [Drosophila melanogaster]

    Status: REVIEWED

  9. NM_166618.3 → NP_726352.1  phosphodiesterase 8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726352.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NNF2
    Related
    FBpp0310591
    Conserved Domains (3) summary
    cd00130
    Location:313 → 393
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:629 → 870
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:317 → 393
    PAS_9; PAS domain

  10. NM_166617.2 → NP_726351.1  phosphodiesterase 8, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726351.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MLR1
    Related
    FBpp0310589
    Conserved Domains (3) summary
    cd00130
    Location:214 → 294
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:530 → 771
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:218 → 294
    PAS_9; PAS domain

  11. NM_001169804.2 → NP_001163275.2  phosphodiesterase 8, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163275.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NNF2
    Conserved Domains (3) summary
    cd00130
    Location:459 → 539
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:775 → 1016
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:463 → 539
    PAS_9; PAS domain

  12. NM_166619.2 → NP_726353.1  phosphodiesterase 8, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726353.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NNF2
    Related
    FBpp0310588
    Conserved Domains (1) summary
    pfam00233
    Location:125 → 366
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JGU6 E1JGU6
Q6NNF2.1 Q6NNF2
Q8IGT9 Q8IGT9
Q8MLR1 Q8MLR1

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