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St1 Sulfotransferase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37742, updated on 4-Jan-2025

Summary

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Official Symbol
St1provided by FlyBase
Official Full Name
Sulfotransferase 1provided by FlyBase
Primary source
FLYBASE:FBgn0034887
Locus tag
Dmel_CG5428
See related
AllianceGenome:FB:FBgn0034887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5428; Dmel\CG5428; dmST1; st1
Summary
Enables sulfotransferase activity. Involved in sulfation and xenobiotic metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic anal pad; embryonic head epidermis; embryonic large intestine; epidermis; and gut section. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital ichthyosis 14; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1B1 (sulfotransferase family 1B member 1); SULT1C3 (sulfotransferase family 1C member 3); and SULT1E1 (sulfotransferase family 1E member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See St1 in Genome Data Viewer
Location:
59F6-59F6; 2-104 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23681623..23682952)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19569146..19570475)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45153 Neighboring gene retained Neighboring gene Phosphodiesterase 8 Neighboring gene lethal (2) essential for life Neighboring gene Sulfotransferase 3 Neighboring gene uncharacterized protein Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster. Aiello G, et al. EMBO Rep, 2022 Sep 5. PMID 35796299, Free PMC Article
  2. Cloning, expression, and characterization of cytosolic sulfotransferase isozymes from Drosophila melanogaster. Hattori K, et al. Biosci Biotechnol Biochem, 2008 Feb. PMID 18256476
  3. Expression analysis of a family of developmentally-regulated cytosolic sulfotransferases (SULTs) in Drosophila. Fahmy K, et al. Hereditas, 2013 Jun. PMID 23865965
  4. [Identification of C(2)M interacting proteins by yeast two-hybrid screening]. Yue SS, et al. Yi Chuan, 2015 Nov. PMID 26582530
  5. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Jimenez-Sanchez M, et al. Nat Chem Biol, 2015 May. PMID 25848931, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
sulfotransferase 1
Names
CG5428-PB
St1-PB
NP_611815.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23681623..23682952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137971.3 → NP_611815.3  sulfotransferase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611815.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9UND3, Q7K2T0, Q9W1L8
    Conserved Domains (1) summary
    pfam00685
    Location:67 → 322
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1L8 Q9W1L8

Gene LinkOut

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