egl egalitarian [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eglprovided by FlyBase
Official Full Name: egalitarianprovided by FlyBase
Primary source: FLYBASE:FBgn0000562
Locus tag: Dmel_CG4051
See related: AllianceGenome:FB:FBgn0000562
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4051; Dmel\CG4051; egal; Egl; EGL
Summary: Enables mRNA binding activity. Involved in several processes, including larval salivary gland morphogenesis; oocyte differentiation; and regulation of oskar mRNA translation. Is expressed in several structures, including clypeo-labral primordium; female germline cell; gut section; larval muscle cell; and visceral trunk mesoderm derivative. Orthologous to human EXD1 (exonuclease 3'-5' domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 59F7-59F7; 2-104 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23734904..23746829, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19622427..19634352, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor.
Title: In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor.
Dynein light chain-dependent dimerization of Egalitarian is essential for maintaining oocyte fate in Drosophila.
Title: Dynein light chain-dependent dimerization of Egalitarian is essential for maintaining oocyte fate in Drosophila.
Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.
Title: Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.
the RNA is required for robust activation of dynein motility. We show that a cis-acting RNA localisation signal promotes the interaction of Egl with BicD, which licenses the latter protein to recruit dynein and dynactin. Our data support a model for BicD activation based on RNA-induced occupancy of two Egl-binding sites on the BicD dimer.
Title: RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs.
artificially dimerized Egl activates dynein-dynactin-BicD in the absence of mRNA. The ability of mRNA cargo to orchestrate the activation of the mRNP (messenger ribonucleotide protein) complex is an elegant way to ensure that only cargo-bound motors are motile.
Title: Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex.
following germline piRNA depletion, abundant maternal HeT-A RNP interacts with Egl resulting in ectopic accumulation of Egl close to the centrosomes during the syncytial stage of embryogenesis; findings suggest that its abnormal localization likely leads to impaired embryonic axis specification typical for piRNA pathway mutants
Title: Subcellular localization and Egl-mediated transport of telomeric retrotransposon HeT-A ribonucleoprotein particles in the Drosophila germline and early embryogenesis.
In the absence of Egl function, oocyte microtubules completely fail to reorganize. Egl also appears to function in regulating the translation of critical polarity determining mRNAs.
Title: Multiple Roles for Egalitarian in Polarization of the Drosophila Egg Chamber.
direct recognition of these mRNA localization signals is mediated by the Egalitarian (Egl) protein
Title: Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor.
component of a selective dynein motor complex that drives transcript localization in a variety of tissues
Title: Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis.
Egl interacts directly with dynein light chain, a microtubule motor component, through an Egl domain distinct from that which binds BicD; data provide a direct link between a molecule necessary for oocyte specification and the microtubule motor complex
Title: Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicoid mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in intracellular mRNA localization involved in pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification	TAS Traceable Author Statement more info	PubMed
involved_in oogenesis	HMP more info	PubMed
involved_in oogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	TAS Traceable Author Statement more info	PubMed
involved_in pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oskar mRNA translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: egalitarian

Names: CG4051-PB; CG4051-PC; egl-PB; egl-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23734904..23746829 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166623.3 → NP_726360.3 egalitarian, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726360.3

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU43, Q9W1K4

Conserved Domains (1) summary

cd06148
Location:541 → 744

Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
NM_001299850.1 → NP_001286779.1 egalitarian, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286779.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU43, Q9W1K4

Conserved Domains (1) summary

cd06148
Location:541 → 744

Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins