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Cpes Ceramide phosphoethanolamine synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37782, updated on 2-Nov-2024

Summary

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Official Symbol
Cpesprovided by FlyBase
Official Full Name
Ceramide phosphoethanolamine synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0025335
Locus tag
Dmel_CG4585
See related
AllianceGenome:FB:FBgn0025335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-60Ab; ces; CG4585; CK00282; CPE; cpes; CPES; dCCS4; Dmel\CG4585; UD2
Summary
Enables ceramide phosphoethanolamine synthase activity. Involved in ceramide phosphoethanolamine biosynthetic process. Located in Golgi apparatus. Is expressed in adult head. Used to study photosensitive epilepsy. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Cpes in Genome Data Viewer
Location:
60A5-60A5; 2-105 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23862962..23865398, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19750485..19752921, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene benign gonial cell neoplasm Neighboring gene Partner of Y14 and Mago Neighboring gene TAR DNA-binding protein-43 homolog Neighboring gene uncharacterized protein Neighboring gene Mitochondrial trifunctional protein beta subunit Neighboring gene ken and barbie

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants. Kunduri G, et al. Proc Natl Acad Sci U S A, 2018 Sep 18. PMID 30185559, Free PMC Article
  2. Wrapping axons in mammals and Drosophila: Different lipids, same principle. Murate M, et al. Biochimie, 2020 Nov. PMID 32800899
  3. Neuronal function and dysfunction of Drosophila dTDP. Lin MJ, et al. PLoS One, 2011. PMID 21673800, Free PMC Article
  4. Developmental inhibition of miR-iab8-3p disrupts mushroom body neuron structure and adult learning ability. Busto GU, et al. Dev Biol, 2016 Nov 15. PMID 27634569, Free PMC Article
  5. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ceramide phosphoethanolamine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ceramide phosphoethanolamine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ceramide phosphoethanolamine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ceramide phosphoethanolamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ceramide phosphoethanolamine synthase
Names
CG4585-PA
CG4585-PB
CG4585-PC
CG4585-PD
CPE synthase
Cpes-PA
Cpes-PB
Cpes-PC
Cpes-PD
undefined 2
NP_001286788.1
NP_001286789.1
NP_001286790.1
NP_477376.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23862962..23865398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058028.5 → NP_477376.1  ceramide phosphoethanolamine synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477376.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77475
    UniProtKB/TrEMBL
    A0A0B4LGC8
    Related
    FBpp0072136
    Conserved Domains (1) summary
    COG0558
    Location:136 → 237
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

  2. NM_001299859.1 → NP_001286788.1  ceramide phosphoethanolamine synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286788.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77475
    UniProtKB/TrEMBL
    A0A0B4LGC8
    Conserved Domains (1) summary
    COG0558
    Location:136 → 237
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

  3. NM_001299860.1 → NP_001286789.1  ceramide phosphoethanolamine synthase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286789.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77475
    UniProtKB/TrEMBL
    A0A0B4LGC8
    Conserved Domains (1) summary
    COG0558
    Location:136 → 237
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

  4. NM_001299861.1 → NP_001286790.1  ceramide phosphoethanolamine synthase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286790.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77475
    UniProtKB/TrEMBL
    A0A0B4LGC8
    Conserved Domains (1) summary
    COG0558
    Location:136 → 237
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGC8 A0A0B4LGC8
O77475.1 O77475

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