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Galphas G protein alpha subunit s [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37805, updated on 9-Dec-2024

Summary

Official Symbol
Galphasprovided by FlyBase
Official Full Name
G protein alpha subunit sprovided by FlyBase
Primary source
FLYBASE:FBgn0001123
Locus tag
Dmel_CG2835
See related
AllianceGenome:FB:FBgn0001123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2835; dgs; DGs; dgsalpha; DGsalpha; dG[[alphas]]; Dmel\CG2835; G-5alpha; G-alpha-60A; G-salpha 60A; G-salpha60A; Gaalpha; Galpha60A; galphas; GalphaS; Galphas60A; Galpha[[s]]; Galpha[[s]]60A; GNAS/L; Gs; Gs-alpha; Gs-alpha60A; Gsalpha; GSalpha; Gsalpha60; Gsalpha60A; G[[alphas]]; G[[s]]; G[[s]]-alpha-60A; G[[s]]alpha; G[[S]]alpha
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including positive regulation of feeding behavior; response to trehalose; and sensory perception of sweet taste. Located in basement membrane and plasma membrane. Part of heterotrimeric G-protein complex. Is active in neuromuscular junction; postsynapse; and presynapse. Is expressed in several structures, including chemosensory sensory organ; embryonic/larval midgut primordium; gut section; larval muscle cell; and organism subdivision. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; dystonia 25; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to several human genes including GNAL (G protein subunit alpha L). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Galphas in Genome Data Viewer
Location:
60A12-60A13; 2-105 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23942538..23946936)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19830061..19834459)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Transaldolase Neighboring gene orcokinin Neighboring gene Stomatin like 2 Neighboring gene fizzy-related 2

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G protein alpha subunit s
Names
CG2835-PA
CG2835-PB
CG2835-PC
CG2835-PD
CG2835-PE
G protein alpha s subunit
G protein salpha 60A
G-alpha s
Galphas-PA
Galphas-PB
Galphas-PC
Galphas-PD
Galphas-PE
Gs small G protein subunit
stimulatory alpha subunit of G protein
NP_001163283.1
  • unusual splice
NP_477505.1
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23942538..23946936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058157.5NP_477505.1  G protein alpha subunit s, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477505.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JGV3, P20354, P20355, Q2MGN1, Q9W1F9
    Related
    FBpp0072052
    Conserved Domains (1) summary
    cd00066
    Location:44379
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  2. NM_058158.5NP_477506.1  G protein alpha subunit s, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477506.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGI1
    Related
    FBpp0072053
    Conserved Domains (1) summary
    cd00066
    Location:44376
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  3. NM_001169812.2NP_001163283.1  G protein alpha subunit s, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163283.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JGV3, P20354, P20355, Q2MGN1, Q9W1F9
    Conserved Domains (1) summary
    cd00066
    Location:44379
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  4. NM_166640.3NP_726388.1  G protein alpha subunit s, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726388.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGI1
    Related
    FBpp0072051
    Conserved Domains (1) summary
    cd00066
    Location:44376
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  5. NM_001299869.1NP_001286798.1  G protein alpha subunit s, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGI1
    Conserved Domains (1) summary
    cd00066
    Location:44376
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)