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Orcokinin orcokinin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37806, updated on 4-Jan-2025

Summary

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Official Symbol
Orcokininprovided by FlyBase
Official Full Name
orcokininprovided by FlyBase
Primary source
FLYBASE:FBgn0034935
Locus tag
Dmel_CG13565
See related
AllianceGenome:FB:FBgn0034935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH09340; CG13565; CG1565; Dmel\CG13565; OK; OK-A; OK-B; Orco; orcokinin
Summary
Involved in male courtship behavior and positive regulation of oogenesis. Is expressed in several structures, including accessory medulla; adult brain; adult ventral nerve cord cell body rind; extraembryonic structure; and gut section. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Orcokinin in Genome Data Viewer
Location:
60A13-60A13; 2-105 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23946959..23949076, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19834482..19836599, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Transaldolase Neighboring gene G protein alpha subunit s Neighboring gene Stomatin like 2 Neighboring gene fizzy-related 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Orcokinin neuropeptides regulate reproduction in the fruit fly, Drosophila melanogaster. Silva V, et al. Insect Biochem Mol Biol, 2021 Dec. PMID 34742859
  2. Isoform-specific expression of the neuropeptide orcokinin in Drosophila melanogaster. Chen J, et al. Peptides, 2015 Jun. PMID 25600008
  3. More Drosophila enteroendocrine peptides: Orcokinin B and the CCHamides 1 and 2. Veenstra JA, et al. Cell Tissue Res, 2014 Sep. PMID 24850274
  4. Spatiotemporal organization of enteroendocrine peptide expression in Drosophila. Jang S, et al. J Neurogenet, 2021 Sep-Dec. PMID 34670462
  5. Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS. Zhang Y, et al. PLoS One, 2011. PMID 22046261, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specification of the Drosophila Orcokinin A neurons by combinatorial coding.
    Title: Specification of the Drosophila Orcokinin A neurons by combinatorial coding.
  2. orcokinin B, CCHamide 1, and CCHamide 2 expression in Drosophila is reported.
    Title: More Drosophila enteroendocrine peptides: Orcokinin B and the CCHamides 1 and 2.
  3. Orcokinin neuropeptides regulate reproduction in the fruit fly, Drosophila melanogaster.
    Title: Orcokinin neuropeptides regulate reproduction in the fruit fly, Drosophila melanogaster.
  4. Existence and differential expression of the two orcokinin isoforms in the Drosophila brain and gut.
    Title: Isoform-specific expression of the neuropeptide orcokinin in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
orcokinin
Names
CG13565-PA
CG13565-PB
CG13565-PC
Drm orcokinin
Orcokinin-PA
Orcokinin-PB
Orcokinin-PC
orcokinin B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23946959..23949076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138008.4 → NP_611852.2  orcokinin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611852.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1F8
    Related
    FBpp0072118

  2. NM_001274231.2 → NP_001261160.1  orcokinin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261160.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHE6

  3. NM_001299870.1 → NP_001286799.1  orcokinin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHE6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHE6 A0A0B4LHE6
Q9W1F8 Q9W1F8

Gene LinkOut

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