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Stoml2 Stomatin like 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37807, updated on 9-Dec-2024

Summary

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Official Symbol
Stoml2provided by FlyBase
Official Full Name
Stomatin like 2provided by FlyBase
Primary source
FLYBASE:FBgn0034936
Locus tag
Dmel_CG2970
See related
AllianceGenome:FB:FBgn0034936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2970; Dmel\CG2970; dmSTOML2; dSLP-2; SD03319p
Summary
Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human STOML2 (stomatin like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Stoml2 in Genome Data Viewer
Location:
60A13-60A13; 2-105 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23949201..23952459)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19836724..19839982)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene G protein alpha subunit s Neighboring gene orcokinin Neighboring gene fizzy-related 2 Neighboring gene uncharacterized protein Neighboring gene thoc5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Zanon A, et al. Hum Mol Genet, 2017 Jul 1. PMID 28379402, Free PMC Article
  2. Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Jacobs H, et al. Curr Biol, 2002 Aug 20. PMID 12194827
  3. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Moon S, et al. Development, 2011 Sep. PMID 21828100
  4. DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Fortuna TR, et al. Acta Neuropathol, 2021 Sep. PMID 34061233, Free PMC Article
  5. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stomatin like 2
Names
CG2970-PA
CG2970-PB
Stoml2-PA
Stoml2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23949201..23952459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138009.3 → NP_611853.2  stomatin like 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611853.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3K9, Q9W1F7
    Related
    FBpp0072054
    Conserved Domains (3) summary
    smart00244
    Location:41 → 199
    PHB; prohibitin homologues
    cd08829
    Location:80 → 188
    SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam16200
    Location:266 → 326
    Band_7_C; C-terminal region of band_7

  2. NM_001274232.1 → NP_001261161.1  stomatin like 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3K9, Q9W1F7
    Conserved Domains (3) summary
    smart00244
    Location:41 → 199
    PHB; prohibitin homologues
    cd08829
    Location:80 → 188
    SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam16200
    Location:266 → 326
    Band_7_C; C-terminal region of band_7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T3K9 Q8T3K9
Q9W1F7 Q9W1F7

Gene LinkOut

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