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fzr2 fizzy-related 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37808, updated on 9-Dec-2024

Summary

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Official Symbol
fzr2provided by FlyBase
Official Full Name
fizzy-related 2provided by FlyBase
Primary source
FLYBASE:FBgn0034937
Locus tag
Dmel_CG16783
See related
AllianceGenome:FB:FBgn0034937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16783; Dmel\CG16783; FZR2
Summary
Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process and male meiotic nuclear division. Predicted to be part of anaphase-promoting complex. Is expressed in organism; spermatocyte; and testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See fzr2 in Genome Data Viewer
Location:
60A13-60A13; 2-105 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23950647..23952096)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19838170..19839619)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene G protein alpha subunit s Neighboring gene orcokinin Neighboring gene Stomatin like 2 Neighboring gene uncharacterized protein Neighboring gene thoc5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Jacobs H, et al. Curr Biol, 2002 Aug 20. PMID 12194827
  2. The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID. Jäger H, et al. Chromosoma, 2005 Feb. PMID 15592865
  3. The anaphase-promoting complex/cyclosome: APC/C. Acquaviva C, et al. J Cell Sci, 2006 Jun 15. PMID 16763193
  4. Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator. Pesin JA, et al. PLoS Genet, 2007 Nov. PMID 18020708, Free PMC Article
  5. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Moon S, et al. Development, 2011 Sep. PMID 21828100

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables anaphase-promoting complex binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in exit from mitosis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in male meiotic nuclear division IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fizzy-related 2
Names
CG16783-PA
fzr2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23950647..23952096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138010.4 → NP_611854.1  fizzy-related 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611854.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1F6
    Related
    FBpp0072055
    Conserved Domains (3) summary
    COG2319
    Location:101 → 439
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:190 → 227
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:190 → 446
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1F6 Q9W1F6

Gene LinkOut

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