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Fmo-1 Flavin-containing monooxygenase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37814, updated on 9-Dec-2024

Summary

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Official Symbol
Fmo-1provided by FlyBase
Official Full Name
Flavin-containing monooxygenase 1provided by FlyBase
Primary source
FLYBASE:FBgn0034943
Locus tag
Dmel_CG3006
See related
AllianceGenome:FB:FBgn0034943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3006; Dmel\CG3006; DmFMO-1; Dmfmo1; FMO-1
Summary
Enables monooxygenase activity. Located in cytosol and mitochondrion. Is expressed in embryonic/larval fat body; embryonic/larval midgut; and yolk nucleus. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO1 (flavin containing dimethylaniline monoxygenase 1); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Fmo-1 in Genome Data Viewer
Location:
60A14-60A14; 2-105 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23962956..23964641)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19850479..19852164)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene thoc5 Neighboring gene uncharacterized protein Neighboring gene alpha-catenin related Neighboring gene uncharacterized protein Neighboring gene Aminolevulinate synthase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catalytic activity and expression of two flavin-containing monooxygenases from Drosophila melanogaster. Scharf ME, et al. Arch Insect Biochem Physiol, 2004 Sep. PMID 15352153
  2. Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo. Wei Q, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jun. PMID 28341216
  3. δ-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva. Shaik KS, et al. Eur J Cell Biol, 2012 Mar. PMID 22293958
  4. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Moon S, et al. Development, 2011 Sep. PMID 21828100
  5. Serotonin and dopamine modulate aging in response to food odor and availability. Miller HA, et al. Nat Commun, 2022 Jun 7. PMID 35672307, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Flavin-containing monooxygenase 1
Names
CG3006-PA
Fmo-1-PA
NP_611859.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23962956..23964641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138015.4 → NP_611859.1  Flavin-containing monooxygenase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611859.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q962N6, Q9W1E9
    Related
    FBpp0072059
    Conserved Domains (1) summary
    cl21454
    Location:5 → 197
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q962N6 Q962N6
Q9W1E9 Q9W1E9

Gene LinkOut

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