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Alas Aminolevulinate synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37815, updated on 9-Dec-2024

Summary

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Official Symbol
Alasprovided by FlyBase
Official Full Name
Aminolevulinate synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0020764
Locus tag
Dmel_CG3017
See related
AllianceGenome:FB:FBgn0020764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alas; ALAS; CG3017; dALAS; Dmel\CG3017
Summary
Predicted to enable 5-aminolevulinate synthase activity. Involved in chitin-based cuticle development. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in Bolwig organ primordium; adult head; embryonic/larval oenocyte; organism; and ring gland. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1) and ALAS2 (5'-aminolevulinate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Alas in Genome Data Viewer
Location:
60A14-60A14; 2-105 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23964772..23966757)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19852295..19854280)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene alpha-catenin related Neighboring gene uncharacterized protein Neighboring gene Flavin-containing monooxygenase 1 Neighboring gene uncharacterized protein Neighboring gene orange Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Relevant expression of Drosophila heme oxygenase is necessary for the normal development of insect tissues. Cui L, et al. Biochem Biophys Res Commun, 2008 Dec 26. PMID 18983822
  2. Structure and regulated expression of the delta-aminolevulinate synthase gene from Drosophila melanogaster. Ruiz de Mena I, et al. J Biol Chem, 1999 Dec 24. PMID 10601299
  3. Catalytic activity and expression of two flavin-containing monooxygenases from Drosophila melanogaster. Scharf ME, et al. Arch Insect Biochem Physiol, 2004 Sep. PMID 15352153
  4. Diphenyl diselenide [(PhSe)2] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity. Golombieski RM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2008 Mar. PMID 17936691
  5. The ABC transporter Snu and the extracellular protein Snsl cooperate in the formation of the lipid-based inward and outward barrier in the skin of Drosophila. Zuber R, et al. Eur J Cell Biol, 2018 Mar. PMID 29306642

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results demonstrated that alas and CG33156 are indispensable for ecdysteroidogenesis.
    Title: Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis.
  2. aminolevulinate synthase activity, which initiates heme biosynthesis in the mitochondrion, is needed for the formation of a dityrosine-based barrier that confers resistance to the internal hydrostatic pressure
    Title: δ-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva.
  3. Delta-ALA-D from D. melanogaster and M.musculus has a different profile of optimum pH and different sensitivity for diphenyl diselenide and lead, two inhibitors.
    Title: Diphenyl diselenide [(PhSe)2] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5-aminolevulinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-aminolevulinate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5-aminolevulinate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in erythrocyte development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hemoglobin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aminolevulinate synthase
Names
Alas-PA
Alas/50-Aminolevulinate synthase
CG3017-PA
delta-Aminolevulinate synthase
delta-aminolevulinic acid synthase
NP_477281.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23964772..23966757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057933.5 → NP_477281.1  aminolevulinate synthase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477281.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18680, Q8T4G6
    Related
    FBpp0072060
    Conserved Domains (2) summary
    COG0156
    Location:95 → 490
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    cl18945
    Location:93 → 495
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18680 O18680
Q8T4G6 Q8T4G6

Gene LinkOut

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