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Sox14 Sox box protein 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37822, updated on 4-Jan-2025

Summary

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Official Symbol
Sox14provided by FlyBase
Official Full Name
Sox box protein 14provided by FlyBase
Primary source
FLYBASE:FBgn0005612
Locus tag
Dmel_CG3090
See related
AllianceGenome:FB:FBgn0005612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17263; CG3090; Dmel\CG3090; Dsox-14; DSox-14; DSox14; DSox60B; Sox-14; sox14; SOX14; SOX60B; SOXC
Summary
Enables DNA binding activity, bending and sequence-specific DNA binding activity. Involved in several processes, including neuron development; positive regulation of neuron remodeling; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; epithelium; gut section; and salivary gland. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 10 and urinary bladder cancer. Orthologous to several human genes including SOX4 (SRY-box transcription factor 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Sox14 in Genome Data Viewer
Location:
60A16-60A16; 2-105 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23978801..23985177)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19866324..19872700)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene morula Neighboring gene Protein phosphatase 1 regulatory subunit 15 Neighboring gene Peptidylglycine-alpha-hydroxylating monooxygenase Neighboring gene uncharacterized protein Neighboring gene PAS kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of an SRY-like gene, DSox14, from Drosophila. Sparkes AC, et al. Gene, 2001 Jul 11. PMID 11470517
  2. A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning. Kirilly D, et al. Nat Neurosci, 2009 Dec. PMID 19881505, Free PMC Article
  3. Ancestry and diversity of the HMG box superfamily. Laudet V, et al. Nucleic Acids Res, 1993 May 25. PMID 8506143, Free PMC Article
  4. PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. Jiang N, et al. Dev Biol, 2000 Oct 1. PMID 10993678
  5. The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species. Yang J, et al. Genome Res, 2012 Nov. PMID 22895281, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sox14 is a critical transcription factor required for 20E signaling at the onset of metamorphosis.
    Title: Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis.
  2. a previously unknown pathway composed of Sox14 and its cytoskeletal target Mical governs dendrite severing during development
    Title: A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in metamorphosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Sox box protein 14
Names
CG3090-PA
CG3090-PB
CG3090-PC
Sox14-PA
Sox14-PB
Sox14-PC
sox box protein 14

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23978801..23985177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299872.1 → NP_001286801.1  Sox box protein 14, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286801.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40656, Q2MGM9, Q9U1H4, Q9W1E2, Q9W1E3
    UniProtKB/TrEMBL
    A0A0B4LGC4
    Conserved Domains (1) summary
    cd01388
    Location:186 → 257
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  2. NM_057546.3 → NP_476894.1  Sox box protein 14, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476894.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40656, Q2MGM9, Q9U1H4, Q9W1E2, Q9W1E3
    UniProtKB/TrEMBL
    A0A0B4LGC4
    Related
    FBpp0072066
    Conserved Domains (1) summary
    cd01388
    Location:186 → 257
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  3. NM_134290.1 → NP_599117.1  Sox box protein 14, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599117.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40656, Q2MGM9, Q9U1H4, Q9W1E2, Q9W1E3
    UniProtKB/TrEMBL
    A0A0B4LGC4
    Related
    FBpp0072067, FBtr0072158
    Conserved Domains (1) summary
    cd01388
    Location:186 → 257
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGC4 A0A0B4LGC4
P40656.3 P40656

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