U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rsph4a Radial spoke head protein 4a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37831, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Rsph4aprovided by FlyBase
Official Full Name
Radial spoke head protein 4aprovided by FlyBase
Primary source
FLYBASE:FBgn0034957
Locus tag
Dmel_CG3121
See related
AllianceGenome:FB:FBgn0034957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.109; CG3121; Dmel\CG3121; dRSPH4a
Summary
Involved in axoneme assembly. Predicted to be part of radial spoke. Predicted to be active in axoneme. Is expressed in adult head; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 11. Orthologous to human RSPH6A (radial spoke head 6 homolog A) and RSPH4A (radial spoke head component 4A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rsph4a in Genome Data Viewer
Location:
60B3-60B3; 2-106 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24017421..24019896)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19904944..19907419)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Obscurin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Xyloside xylosyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila. Wang Y, et al. J Genet Genomics, 2019 Jun 20. PMID 31281031
  2. Candidate transcriptomic sources of inbreeding depression in Drosophila melanogaster. Garcia C, et al. PLoS One, 2013. PMID 23922905, Free PMC Article
  3. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
  4. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article
  5. Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm. Ramesh R, et al. Antioxid Redox Signal, 2023 Jun. PMID 36509450, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement involved in cell motility IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of radial spoke IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
radial spoke head protein 4a
Names
CG3121-PA
Rsph4a-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24017421..24019896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138025.3 → NP_611869.1  radial spoke head protein 4a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1D3
    Related
    FBpp0072070
    Conserved Domains (1) summary
    pfam04712
    Location:83 → 679
    Radial_spoke; Radial spokehead-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1D3 Q9W1D3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools