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IntS1 Integrator 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37840, updated on 9-Dec-2024

Summary

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Official Symbol
IntS1provided by FlyBase
Official Full Name
Integrator 1provided by FlyBase
Primary source
FLYBASE:FBgn0034964
Locus tag
Dmel_CG3173
See related
AllianceGenome:FB:FBgn0034964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3173; Dmel\CG3173; Int1; intS1
Summary
Involved in positive regulation of neuron differentiation and snRNA 3'-end processing. Predicted to be part of integrator complex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See IntS1 in Genome Data Viewer
Location:
60B5-60B5; 2-106 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24037943..24044458)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19925466..19931981)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene MAN1 Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene twinstar Neighboring gene gamma Soluble NSF attachment protein 1 Neighboring gene seizure Neighboring gene pickpocket 29 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Elrod ND, et al. Mol Cell, 2019 Dec 5. PMID 31809743, Free PMC Article
  2. Inositol hexakisphosphate is required for Integrator function. Lin MH, et al. Nat Commun, 2022 Sep 30. PMID 36180473, Free PMC Article
  3. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
  4. The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells. Zhang Y, et al. Cell Rep, 2019 Apr 23. PMID 31018143
  5. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in U2 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U2 snRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
integrator 1
Names
CG3173-PA
IntS1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24037943..24044458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138031.3 → NP_611875.1  integrator 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IGA9, Q9W1C5
    Related
    FBpp0072077
    Conserved Domains (1) summary
    pfam12432
    Location:327 → 407
    DUF3677; Protein of unknown function (DUF3677)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1C5.2 Q9W1C5

Gene LinkOut

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