tsr twinstar [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tsrprovided by FlyBase
Official Full Name: twinstarprovided by FlyBase
Primary source: FLYBASE:FBgn0011726
Locus tag: Dmel_CG4254
See related: AllianceGenome:FB:FBgn0011726
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 12/8; Adf; ADF; ADF/cofilin; Cadf; cfl; Cfl; CG4254; cofilin; Cofilin; cofilin/actin depolymerizing factor homolog; cofilin/ADF; D-cof; D61; DmCFL; Dmel\CG4254; l(2)03101; l(2)k03101; l(2)k05633; l(2)k13409; ntf; T8; Tsr; Twinstar
Summary: Enables actin binding activity. Involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and nervous system development. Located in cytosol and nucleoplasm. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; follicle cell; and nurse cell. Used to study alcohol use disorder; autism spectrum disorder; and nemaline myopathy 7. Orthologous to human CFL1 (cofilin 1) and DSTN (destrin, actin depolymerizing factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60B5-60B5; 2-106 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24044453..24046805, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19931976..19934328, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cofilin regulates axon growth and branching of Drosophila gamma-neurons.
Title: Cofilin regulates axon growth and branching of Drosophila γ-neurons.
Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth.
Title: Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth.
Cofilin expression in mushroom bodies regulates actin filament dynamics and acquisition of alcohol consumption preference.
Title: Altered Actin Filament Dynamics in the Drosophila Mushroom Bodies Lead to Fast Acquisition of Alcohol Consumption Preference.
Data suggest that actin-interacting protein 1 (AIP1) and twinstar protein (Drosophila cofilin gene) achieve an optimal balance between resistance to tissue tension and morphogenesis.
Title: AIP1 and cofilin ensure a resistance to tissue tension and promote directional cell rearrangement.
study of the structure, backbone dynamics, and biochemical activities of Twinstar; strong affinity for ADP-G-Actin and ATP-G-Actin; mild F-actin depolymerizing activity and stable interaction with F-actin
Title: Structure, dynamics, and biochemical characterization of ADF/cofilin Twinstar from Drosophilamelanogaster.
Taken together, our data suggest that Tsr is required for cell survival and tissue growth by regulating JNK and Yki signaling while maintaining the epithelial integrity by controlling cell junctions. This study provides an insight into potential roles of ADF/cofilin in invasive cell migration and tumor suppression in higher animals.
Title: Twinstar/cofilin is required for regulation of epithelial integrity and tissue growth in Drosophila.
Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties
Title: F-actin dismantling through a redox-driven synergy between Mical and cofilin.
Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.
Title: Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Title: AIP1 acts with cofilin to control actin dynamics during epithelial morphogenesis.
Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.
Title: Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IEA Inferred from Electronic Annotation more info
involved_in actin filament depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin contractile ring assembly	TAS Traceable Author Statement more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in nucleoplasm	HDA more info	PubMed

General protein information

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Preferred Names: twinstar

Names: ADFcofilin; CG4254-PA; Cofilin/actin depolymerizing factor-like; DCofilin; actin-depolymerizing factor; cofilin; no terminal filament; tsr-PA; twin star

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24044453..24046805 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057686.4 → NP_477034.1 twinstar [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477034.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C6SV25, P45594, Q9W1C4

UniProtKB/TrEMBL

A0A1B2AKQ4

Related

FBpp0072097

Conserved Domains (1) summary

cd11286
Location:3 → 142

ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors