ppk29 pickpocket 29 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ppk29provided by FlyBase
Official Full Name: pickpocket 29provided by FlyBase
Primary source: FLYBASE:FBgn0034965
Locus tag: Dmel_CG13568
See related: AllianceGenome:FB:FBgn0034965
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13568; Dmel\CG13568; nope; Ppk29
Summary: Predicted to enable ligand-gated sodium channel activity. Involved in several processes, including detection of pheromone; inter-male aggressive behavior; and male courtship behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult gustatory receptor neurons; adult optic lobe neurons; adult sensillum; and ganglia. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 60B6-60B6; 2-106 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24052917..24057137, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19940440..19944660, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Members of the degenerin/epithelial sodium channel (DEG/ENaC) family are broadly expressed in epithelial and neuronal tissues. To date, the neurophysiological functions of most family members remain unknown. Here, by using the power of Drosophila genetics in combination with electrophysiological and behavioral approaches, we demonstrate that the DEG/ENaC-encoding gene pickpocket 29 contributes to baseline transmission.
Title: The Drosophila Postsynaptic DEG/ENaC Channel ppk29 Contributes to Excitatory Neurotransmission.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0327 (e-PCR)
- UniSTS:25233

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IC Inferred by Curator more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in detection of pheromone	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect male courtship behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pickpocket 29

Names: CG13568-PD; CG13568-PE; CG13568-PF; CG13568-PG; CG13568-PH; not passionate; ppk29-PD; ppk29-PE; ppk29-PF; ppk29-PG; ppk29-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24052917..24057137 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299886.1 → NP_001286815.1 pickpocket 29, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286815.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGF3, A0AVU8

Conserved Domains (1) summary

cl02990
Location:123 → 297

ASC; Amiloride-sensitive sodium channel
NM_001103972.3 → NP_001097442.2 pickpocket 29, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097442.2

Status: REVIEWED

UniProtKB/TrEMBL

A8DYP1

Conserved Domains (1) summary

pfam00858
Location:123 → 415

ASC; Amiloride-sensitive sodium channel
NM_001103971.3 → NP_001097441.1 pickpocket 29, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097441.1

Status: REVIEWED

UniProtKB/TrEMBL

A0AVU8, A8DYP2

Conserved Domains (1) summary

cl02990
Location:123 → 297

ASC; Amiloride-sensitive sodium channel
NM_001144277.2 → NP_001137749.1 pickpocket 29, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137749.1

Status: REVIEWED

UniProtKB/TrEMBL

A8DYP1

Conserved Domains (1) summary

pfam00858
Location:123 → 415

ASC; Amiloride-sensitive sodium channel
NM_001144276.2 → NP_001137748.1 pickpocket 29, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137748.1

Status: REVIEWED

UniProtKB/TrEMBL

A0AVU8, A8DYP2

Conserved Domains (1) summary

cl02990
Location:123 → 297

ASC; Amiloride-sensitive sodium channel