U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

yki yorkie [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37851, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
ykiprovided by FlyBase
Official Full Name
yorkieprovided by FlyBase
Primary source
FLYBASE:FBgn0034970
Locus tag
Dmel_CG4005
See related
AllianceGenome:FB:FBgn0034970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4005; Dmel\CG4005; yap; Yap; YAP; Yap/Taz; Yki; YKI; Yorkie
Summary
Enables several functions, including 14-3-3 protein binding activity; kinase binding activity; and transcription coactivator activity. Involved in several processes, including R8 cell development; epithelial cell differentiation; and regulation of cell development. Located in cytosol; lateral cell cortex; and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including CNS glial cell; cortical zone of lymph gland primary lobe; crystal cell primordium; embryonic/larval crystal cell; and embryonic/larval optic stalk. Used to study cancer (multiple); heart disease; nephrolithiasis; and neurodegenerative disease. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to several human genes including YAP1 (Yes1 associated transcriptional regulator). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See yki in Genome Data Viewer
Location:
60B7-60B8; 2-106 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24065975..24068485, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19953498..19956008, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L12 Neighboring gene Ribosomal protein L39 Neighboring gene Ras-associated protein 2-like Neighboring gene Glycerol-3-phosphate acyltransferase 4 Neighboring gene Muscle LIM protein at 60A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Protocol to analyze Drosophila intestinal tumor cellular heterogeneity using immunofluorescence imaging and nuclear size quantification. Pranoto IKA, et al. STAR Protoc, 2024 Jun 21. PMID 38470911, Free PMC Article
  2. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Zhao B, et al. Cancer Res, 2009 Feb 1. PMID 19141641
  3. Mutant analysis by rescue gene excision: New tools for mosaic studies in Drosophila. Zhou Q, et al. Genesis, 2016 Nov. PMID 27696669, Free PMC Article
  4. Forced into shape: Mechanical forces in Drosophila development and homeostasis. Paci G, et al. Semin Cell Dev Biol, 2021 Dec. PMID 34092509, Free PMC Article
  5. The regulation and function of YAP transcription co-activator. Zhu C, et al. Acta Biochim Biophys Sin (Shanghai), 2015 Jan. PMID 25487920

See all (751) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
    Title: Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
  2. Ca[2+]-calpains axis regulates Yki stability and activity in Drosophila.
    Title: Ca(2+)-calpains axis regulates Yki stability and activity in Drosophila.
  3. Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila.
    Title: Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila.
  4. Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
    Title: Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
  5. Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence.
    Title: Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence.
  6. JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
    Title: JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
  7. Modulation of Yorkie activity by alternative splicing is required for developmental stability.
    Title: Modulation of Yorkie activity by alternative splicing is required for developmental stability.
  8. Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila.
    Title: Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila.
  9. The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
    Title: The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
  10. Silence of yki by miR-7 regulates the Hippo pathway.
    Title: Silence of yki by miR-7 regulates the Hippo pathway.
Submit: New GeneRIF Correction See all GeneRIFs (90)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in R8 cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apical protein localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell competition in a multicellular organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of imaginal disc growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
yorkie
Names
CG4005-PD
CG4005-PF
CG4005-PG
CG4005-PH
yki-PD
yki-PF
yki-PG
yki-PH
yorki

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24065975..24068485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166657.5 → NP_726414.3  yorkie, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726414.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2RVH0, A2RVH4, Q0E8X1, Q45VV3, Q7KVG6, Q95TU5, Q9W1B6
    UniProtKB/TrEMBL
    A0A0C4DHD4
    Conserved Domains (2) summary
    pfam00397
    Location:243 → 272
    WW; WW domain
    pfam15238
    Location:57 → 100
    FAM181; FAM181

  2. NM_138035.3 → NP_611879.4  yorkie, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611879.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q45VV3
    Conserved Domains (2) summary
    pfam00397
    Location:243 → 272
    WW; WW domain
    pfam15238
    Location:57 → 100
    FAM181; FAM181

  3. NM_001363931.1 → NP_001350857.1  yorkie, isoform H [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H0RNA4
    Conserved Domains (2) summary
    COG5021
    Location:261 → 404
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:266 → 295
    WW; WW domain

  4. NM_001043103.2 → NP_001036568.2  yorkie, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036568.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2RVH0, A2RVH4, Q0E8X1, Q45VV3, Q7KVG6, Q95TU5, Q9W1B6
    UniProtKB/TrEMBL
    A0A0C4DHD4
    Conserved Domains (2) summary
    pfam00397
    Location:243 → 272
    WW; WW domain
    pfam15238
    Location:57 → 100
    FAM181; FAM181
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0C4DHD4 A0A0C4DHD4
H0RNA4 H0RNA4
Q45VV3.2 Q45VV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools