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Naa35 N(alpha)-acetyltransferase 35 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37866, updated on 9-Dec-2024

Summary

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Official Symbol
Naa35provided by FlyBase
Official Full Name
N(alpha)-acetyltransferase 35provided by FlyBase
Primary source
FLYBASE:FBgn0034982
Locus tag
Dmel_CG4065
See related
AllianceGenome:FB:FBgn0034982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Nelson1; CG4065; Dmel\CG4065
Summary
Predicted to be involved in negative regulation of apoptotic process. Part of NatC complex. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Naa35 in Genome Data Viewer
Location:
60B12-60B12; 2-106 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24135180..24138050, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20022703..20025573, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tamo Neighboring gene long non-coding RNA:CR44826 Neighboring gene Zinc finger protein RP-8 Neighboring gene speck Neighboring gene DnaJ-like-60 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Varland S, et al. Nat Commun, 2023 Oct 27. PMID 37891180, Free PMC Article
  2. Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Rathore OS, et al. Sci Rep, 2016 Feb 10. PMID 26861501, Free PMC Article
  3. Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction. François CM, et al. Nat Commun, 2023 Oct 23. PMID 37872135, Free PMC Article
  4. Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization. Menoret D, et al. Genome Biol, 2013 Aug 23. PMID 23972280, Free PMC Article
  5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatC complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N(alpha)-acetyltransferase 35
Names
CG4065-PA
CG4065-PB
Naa35-PA
Naa35-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24135180..24138050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014546.2 → NP_001014546.1  N(alpha)-acetyltransferase 35, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014546.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V8E9
    Conserved Domains (1) summary
    pfam04112
    Location:95 → 229
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

  2. NM_138047.3 → NP_611891.1  N(alpha)-acetyltransferase 35, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611891.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q59E64, Q8T3X5, Q9W1A2
    Related
    FBpp0072187
    Conserved Domains (1) summary
    pfam04112
    Location:96 → 230
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1A2.1 Q9W1A2

Gene LinkOut

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