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Slik Sterile20-like kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37893, updated on 4-Jan-2025

Summary

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Official Symbol
Slikprovided by FlyBase
Official Full Name
Sterile20-like kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0035001
Locus tag
Dmel_CG4527
See related
AllianceGenome:FB:FBgn0035001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4527; Dmel\CG4527; dPlkk; dPlkk/Slik; DPlkk1; Plkk/Slik; Plkk1; PLKK1; slik; SLIK; Slik1; slk; Slk; SLK
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cytoskeleton organization; metaphase/anaphase transition of mitotic cell cycle; and rhabdomere membrane biogenesis. Located in several cellular components, including cleavage furrow; mitotic spindle midzone; and rhabdomere. Is expressed in adult head and spermatozoon. Orthologous to several human genes including SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Slik in Genome Data Viewer
Location:
60C7-60C8; 2-106 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24392129..24402680, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20279652..20290203, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene muscarinic Acetylcholine Receptor, A-type Neighboring gene long non-coding RNA:CR44813 Neighboring gene Regulatory particle non-ATPase 8 Neighboring gene Serotonin transporter Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Z

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila orthologue of xPlkk1 is not essential for Polo activation and is necessary for proper contractile ring formation. Alves PS, et al. Exp Cell Res, 2006 Feb 1. PMID 16337190
  2. Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase. Hughes SC, et al. J Cell Biol, 2006 Oct 23. PMID 17060498, Free PMC Article
  3. Slik phosphorylation of Talin T152 is crucial for proper Talin recruitment and maintenance of muscle attachment in Drosophila. Katzemich A, et al. Development, 2019 Oct 3. PMID 31511253
  4. The Ste20-like kinase - a Jack of all trades? Garland B, et al. J Cell Sci, 2021 May 1. PMID 33961052
  5. PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit. Kunda P, et al. Curr Biol, 2012 Feb 7. PMID 22209527

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The conserved C-terminal coiled-coil domain of Slik, which is necessary and sufficient for apical localization of the kinase in epithelial cells, is not required for Moesin phosphorylation but is critical for the growth-promoting function of Slik.
    Title: Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment Phosphorylation.
  2. Slik acts via distinct pathways to coordinate cell proliferation with epithelial cell behavior during tissue growth.
    Title: Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth.
  3. Slik mediates growth and survival cues to promote cell proliferation and control cell survival during Drosophila development
    Title: The Drosophila sterile-20 kinase slik controls cell proliferation and apoptosis during imaginal disc development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in branching involved in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sterile20-like kinase
Names
CG4527-PA
CG4527-PB
CG4527-PD
CG4527-PE
CG4527-PF
CG4527-PG
Slik-PA
Slik-PB
Slik-PD
Slik-PE
Slik-PF
Slik-PG
Ste20 kinase
Sterile-20
dPlkk/Slik threonine kinase
polo kinase kinase 1
sterile 20-like kinase
NP_001014549.1
NP_001137752.1
NP_611908.2
NP_726441.1
NP_995935.1
NP_995936.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24392129..24402680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166669.4 → NP_726441.1  Sterile20-like kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726441.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W179
    Related
    FBpp0072271
    Conserved Domains (3) summary
    cd06611
    Location:31 → 310
    STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
    smart00220
    Location:37 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:1126 → 1266
    PKK; Polo kinase kinase

  2. NM_206214.4 → NP_995936.2  Sterile20-like kinase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995936.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZU8, Q7YZB2
    Conserved Domains (3) summary
    cd06611
    Location:31 → 310
    STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
    smart00220
    Location:37 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:1140 → 1280
    PKK; Polo kinase kinase

  3. NM_206213.3 → NP_995935.1  Sterile20-like kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995935.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W179
    Conserved Domains (3) summary
    cd06611
    Location:31 → 310
    STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
    smart00220
    Location:37 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:1126 → 1266
    PKK; Polo kinase kinase

  4. NM_001014549.3 → NP_001014549.1  Sterile20-like kinase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014549.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59E61, Q7YZB2
    Conserved Domains (3) summary
    cd06611
    Location:31 → 310
    STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
    smart00220
    Location:37 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:1126 → 1266
    PKK; Polo kinase kinase

  5. NM_001144280.2 → NP_001137752.1  Sterile20-like kinase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZQ1, Q7YZB2
    Conserved Domains (3) summary
    cd06611
    Location:31 → 310
    STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
    smart00220
    Location:37 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:1126 → 1266
    PKK; Polo kinase kinase

  6. NM_138064.4 → NP_611908.2  Sterile20-like kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611908.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YZB2, Q8MLP1
    Related
    FBpp0072270
    Conserved Domains (3) summary
    cd06611
    Location:31 → 310
    STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
    smart00220
    Location:37 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:1126 → 1266
    PKK; Polo kinase kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4UZU8 A4UZU8
B7YZQ1 B7YZQ1
Q59E61 Q59E61
Q7YZB2 Q7YZB2
Q8MLP1 Q8MLP1
Q8MRH6 Q8MRH6
Q95U41 Q95U41
Q9W179 Q9W179

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