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uri unconventional prefoldin RPB5 interactor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37924, updated on 9-Dec-2024

Summary

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Official Symbol
uriprovided by FlyBase
Official Full Name
unconventional prefoldin RPB5 interactorprovided by FlyBase
Primary source
FLYBASE:FBgn0035025
Locus tag
Dmel_CG11416
See related
AllianceGenome:FB:FBgn0035025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11416; Dmel\CG11416; dURI; ori
Summary
Enables phosphatase inhibitor activity. Involved in spermatogenesis. Located in cytoplasm and polytene chromosome. Is expressed in several structures, including imaginal disc; larval brain; male germline cell; salivary gland; and testis. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See uri in Genome Data Viewer
Location:
60D5-60D5; 2-107 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24565554..24568082)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20453077..20455605)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nucleosome remodeling factor - 38kD Neighboring gene uncharacterized protein Neighboring gene TFIIF-interacting CTD phosphatase Neighboring gene uncharacterized protein Neighboring gene Start1 Neighboring gene SIFamide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Uri, a PP1alpha binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity. Kirchner J, et al. BMC Mol Biol, 2008 Apr 15. PMID 18412953, Free PMC Article
  2. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
  3. Tissue, cell type and stage-specific ectopic gene expression and RNAi induction in the Drosophila testis. White-Cooper H. Spermatogenesis, 2012 Jan 1. PMID 22553486, Free PMC Article
  4. Molecular profiling of stem cell-like female germ line cells in Drosophila delineates networks important for stemness and differentiation. Tiwari MD, et al. Biol Open, 2019 Nov 12. PMID 31649115, Free PMC Article
  5. The Drosophila melanogaster sperm proteome-II (DmSP-II). Wasbrough ER, et al. J Proteomics, 2010 Oct 10. PMID 20833280

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
unconventional prefoldin RPB5 interactor
Names
CG11416-PA
origami
uri-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24565554..24568082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138089.4 → NP_611933.1  unconventional prefoldin RPB5 interactor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611933.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T044, Q9W148
    Related
    FBpp0072215
    Conserved Domains (1) summary
    pfam02996
    Location:8 → 124
    Prefoldin; Prefoldin subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W148.1 Q9W148

Gene LinkOut

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