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pio piopio [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37929, updated on 4-Jan-2025

Summary

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Official Symbol
pioprovided by FlyBase
Official Full Name
piopioprovided by FlyBase
Primary source
FLYBASE:FBgn0020521
Locus tag
Dmel_CG3541
See related
AllianceGenome:FB:FBgn0020521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30167; CG3541; Dmel\CG3541; Pio
Summary
Involved in several processes, including apposition of dorsal and ventral imaginal disc-derived wing surfaces; chitin-based cuticle attachment to epithelium; and chitin-based embryonic cuticle biosynthetic process. Located in apical part of cell. Is expressed in tracheal lumen. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pio in Genome Data Viewer
Location:
60D7-60D8; 2-107 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24581245..24597862)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20468768..20485385)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Start1 Neighboring gene uncharacterized protein Neighboring gene SIFamide Neighboring gene uncharacterized protein Neighboring gene ATP synthase, subunit F Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Jaźwińska A, et al. Nat Cell Biol, 2003 Oct. PMID 12973360
  2. Tubulogenesis: zipping up your fly. Paul SM, et al. Curr Biol, 2005 Jan 26. PMID 15668162
  3. Watching tubules glow and branch. Davies JA. Curr Opin Genet Dev, 2005 Aug. PMID 15964757
  4. Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin. JayaNandanan N, et al. Nat Commun, 2014. PMID 24413568, Free PMC Article
  5. Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner. Baer MM, et al. J Cell Sci, 2012 Dec 15. PMID 23132924

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we demonstrate that Tpr zymogen and the ZP domain of the ECM protein Piopio are cleaved by Np and matriptase in vitro.
    Title: Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based cuticle attachment to epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based embryonic cuticle biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
piopio
Names
CG3541-PB
CG3541-PC
CG3541-PD
CG3541-PE
pio-PB
pio-PC
pio-PD
pio-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24581245..24597862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169824.2 → NP_001163295.1  piopio, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163295.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRK0
    Conserved Domains (2) summary
    smart00241
    Location:66 → 349
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:248 → 349
    Zona_pellucida; Zona pellucida-like domain

  2. NM_166677.3 → NP_726461.1  piopio, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726461.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRK0
    Related
    FBpp0072219
    Conserved Domains (2) summary
    smart00241
    Location:66 → 349
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:248 → 349
    Zona_pellucida; Zona pellucida-like domain

  3. NM_138094.4 → NP_611938.2  piopio, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611938.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W143
    Related
    FBpp0072220

  4. NM_001299920.1 → NP_001286849.1  piopio, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286849.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRK0
    Conserved Domains (2) summary
    smart00241
    Location:66 → 349
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:248 → 349
    Zona_pellucida; Zona pellucida-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IRK0 Q8IRK0
Q95T91 Q95T91
Q9W143 Q9W143

Gene LinkOut

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