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Samtor S-adenosylmethionine sensor upstream of TORC1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37934, updated on 9-Dec-2024

Summary

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Official Symbol
Samtorprovided by FlyBase
Official Full Name
S-adenosylmethionine sensor upstream of TORC1provided by FlyBase
Primary source
FLYBASE:FBgn0035035
Locus tag
Dmel_CG3570
See related
AllianceGenome:FB:FBgn0035035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3570; Dmel\CG3570; dSamtor; dSAMTOR; samtor; SAMTOR
Summary
Enables S-adenosyl-L-methionine binding activity and amino acid sensor activity. Involved in cellular response to amino acid starvation; cellular response to methionine; and negative regulation of TORC1 signaling. Orthologous to human BMT2 (base methyltransferase of 25S rRNA 2 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Samtor in Genome Data Viewer
Location:
60D9-60D9; 2-107 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24603572..24604670)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20491095..20492193)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene aarF domain containing kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during Drosophila Aging: A Tissue-Specific Pathology. Katarachia SA, et al. Int J Mol Sci, 2023 Jun 2. PMID 37298625, Free PMC Article
  2. Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Tang X, et al. Sci Adv, 2022 Jul. PMID 35776786, Free PMC Article
  3. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Gu X, et al. Science, 2017 Nov 10. PMID 29123071, Free PMC Article
  4. Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number. Gardiol A, et al. Dev Biol, 2014 Aug 15. PMID 24951879, Free PMC Article
  5. An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Liu GY, et al. Nat Commun, 2024 Mar 21. PMID 38514639, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to methionine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
S-adenosylmethionine sensor upstream of TORC1
Names
CG3570-PA
S-adenosylmethionine sensor upstream of mTORC1
Samtor-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24603572..24604670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138099.3 → NP_611943.1  S-adenosylmethionine sensor upstream of TORC1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611943.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W138
    Related
    FBpp0072224
    Conserved Domains (1) summary
    cl17173
    Location:186 → 266
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W138.1 Q9W138

Gene LinkOut

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