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Pof Painting of fourth [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37947, updated on 4-Jan-2025

Summary

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Official Symbol
Pofprovided by FlyBase
Official Full Name
Painting of fourthprovided by FlyBase
Primary source
FLYBASE:FBgn0035047
Locus tag
Dmel_CG3691
See related
AllianceGenome:FB:FBgn0035047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg3691; CG3691; Dmel\CG3691; pof; POF
Summary
Enables chromatin binding activity. Involved in positive regulation of gene expression. Located in autosome and polytene chromosome. Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pof in Genome Data Viewer
Location:
60D13-60D13; 2-107 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24669397..24671577)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20556920..20559100)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Matrix metalloproteinase 1 Neighboring gene Sialyltransferase Neighboring gene Mid1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Painting of fourth, a chromosome-specific protein in Drosophila. Larsson J, et al. Proc Natl Acad Sci U S A, 2001 May 22. PMID 11353870, Free PMC Article
  2. Buffering of segmental and chromosomal aneuploidies in Drosophila melanogaster. Stenberg P, et al. PLoS Genet, 2009 May. PMID 19412336, Free PMC Article
  3. Genome-wide mapping of Painting of fourth on Drosophila melanogaster salivary gland polytene chromosomes. Johansson AM, et al. Genom Data, 2014 Dec. PMID 26484072, Free PMC Article
  4. POF regulates the expression of genes on the fourth chromosome in Drosophila melanogaster by binding to nascent RNA. Johansson AM, et al. Mol Cell Biol, 2012 Jun. PMID 22473994, Free PMC Article
  5. Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1. Tzeng TY, et al. Proc Natl Acad Sci U S A, 2007 Jul 31. PMID 17652514, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Painting of Fourth and the X-Linked 1.688 Satellite in D. melanogaster is Involved in Chromosome-Wide Gene Regulation.
    Title: Painting of Fourth and the X-Linked 1.688 Satellite in D. melanogaster is Involved in Chromosome-Wide Gene Regulation.
  2. The targeting of protein Painting of fourth to PoX1(POF-on-X) and PoX2 is largely dependent on roX expression and identified a high-affinity target region that ectopically recruits POF.
    Title: Targeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the fourth chromosome in Drosophila melanogaster.
  3. POF binds to nascent RNA, and this binding is associated with increased transcription output from chromosome 4
    Title: POF regulates the expression of genes on the fourth chromosome in Drosophila melanogaster by binding to nascent RNA.
  4. Together with Egg, Wde (Windei) localizes to euchromatin, is enriched on chromosome 4, and binds to the Painting of fourth (POF) protein.
    Title: Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development.
  5. These results suggest a balancing mechanism for the regulation of the fourth chromosome where POF and HP1 competitively bind at increasing levels with increased transcriptional activity.
    Title: POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation.
  6. POF is involved in a chromosome-specific regulatory function
    Title: Painting of fourth in genus Drosophila suggests autosome-specific gene regulation.
  7. There is a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome.
    Title: Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in autosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
painting of fourth
Names
CG3691-PA
CG3691-PB
CG3691-PC
Pof-PA
Pof-PB
Pof-PC
painting of fourth chromosome
painting on the fourth
painting-of-fourth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24669397..24671577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079127.3 → NP_523851.1  painting of fourth, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523851.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8W2, Q9W123
    UniProtKB/TrEMBL
    A0A0B4K883
    Related
    FBpp0072234
    Conserved Domains (2) summary
    COG0724
    Location:201 → 292
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:217 → 285
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_166682.3 → NP_726472.1  painting of fourth, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726472.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8W2, Q9W123
    UniProtKB/TrEMBL
    A0A0B4K883
    Related
    FBpp0072235
    Conserved Domains (2) summary
    COG0724
    Location:201 → 292
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:217 → 285
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001259569.2 → NP_001246498.1  painting of fourth, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246498.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8W2, Q9W123
    UniProtKB/TrEMBL
    A0A0B4K883
    Conserved Domains (2) summary
    COG0724
    Location:201 → 292
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:217 → 285
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K883 A0A0B4K883
Q9W123.1 Q9W123

Gene LinkOut

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