TyrRS-m Tyrosyl-tRNA synthetase, mitochondrial [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TyrRS-mprovided by FlyBase
Official Full Name: Tyrosyl-tRNA synthetase, mitochondrialprovided by FlyBase
Primary source: FLYBASE:FBgn0035064
Locus tag: Dmel_CG16912
See related: AllianceGenome:FB:FBgn0035064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Aatm; Aats-try-m; Aats-tyr-m; anon-EST:fe1E12; CG16912; Dmel\CG16912
Summary: Predicted to enable tyrosine-tRNA ligase activity. Predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24781726..24783500, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20669249..20671023, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables tyrosine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tyrosine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables tyrosine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tyrosine-tRNA ligase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial tyrosyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tyrosyl-tRNA aminoacylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

Names: CG16912-PA; TyrRS-m-PA; anon-fast-evolving-1E12; mitochondrial tyrosyl-tRNA synthetase

NP_611967.1

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The following sections contain reference sequences that belong to a specific genome build. Explain