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uzip unzipped [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38002, updated on 4-Jan-2025

Summary

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Official Symbol
uzipprovided by FlyBase
Official Full Name
unzippedprovided by FlyBase
Primary source
FLYBASE:FBgn0004055
Locus tag
Dmel_CG3533
See related
AllianceGenome:FB:FBgn0004055
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3533; Dmel\CG3533; nzip; Uzip; zip
Summary
Involved in axon guidance and axonal fasciculation. Located in plasma membrane. Is expressed in several structures, including adult head; ganglia; glial cell; gut section; and neuroblasts. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See uzip in Genome Data Viewer
Location:
60E12-60F1; 2-107 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (25012062..25031737)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20899585..20919260)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene epithelial membrane protein Neighboring gene uncharacterized protein Neighboring gene zipper Neighboring gene Neuropeptide-like precursor 1 Neighboring gene gooseberry-neuro

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Zipper encodes a putative integral membrane protein required for normal axon patterning during Drosophila neurogenesis. Zhao DB, et al. EMBO J, 1988 Apr. PMID 3402433, Free PMC Article
  2. Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. Mansfield SG, et al. J Mol Biol, 1996 Jan 12. PMID 8568878
  3. Generation and characterization of inner photoreceptor-specific enhancer-trap lines using a novel piggyBac-Gal4 element in Drosophila. Terzioğlu Kara E, et al. Arch Insect Biochem Physiol, 2020 Jun. PMID 32285519
  4. Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila. Ding ZY, et al. Dev Dyn, 2011 Jan. PMID 21117153
  5. Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development. Ma J, et al. G3 (Bethesda), 2016 Aug 9. PMID 27261002, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uzip is a novel cell adhesion molecule from the longitudinal glia regulating axon guidance.
    Title: Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
unzipped
Names
CG3533-PA
CG3533-PB
not-zipper
uzip-PA
uzip-PB
zipper

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    25012062..25031737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299946.1 → NP_001286875.1  unzipped, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10379, Q960B4, Q9W0W7
    UniProtKB/TrEMBL
    A0A0B4LGL6
    Conserved Domains (1) summary
    cl26423
    Location:74 → 159
    DUF3421; Protein of unknown function (DUF3421)

  2. NM_079137.3 → NP_523861.1  unzipped, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523861.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10379, Q960B4, Q9W0W7
    UniProtKB/TrEMBL
    A0A0B4LGL6
    Related
    FBpp0072304
    Conserved Domains (1) summary
    cl26423
    Location:74 → 159
    DUF3421; Protein of unknown function (DUF3421)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGL6 A0A0B4LGL6
P10379.2 P10379

Gene LinkOut

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