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Nplp1 Neuropeptide-like precursor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38003, updated on 9-Dec-2024

Summary

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Official Symbol
Nplp1provided by FlyBase
Official Full Name
Neuropeptide-like precursor 1provided by FlyBase
Primary source
FLYBASE:FBgn0035092
Locus tag
Dmel_CG3441
See related
AllianceGenome:FB:FBgn0035092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
APK; CG3441; Dmel\CG3441; IPNa; IPNamide; MTY-amide; MTYa; MTYamide; NPLP-1; nplp1; NPLP1; VQQ
Summary
Enables neuropeptide hormone activity. Involved in receptor guanylyl cyclase signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including DN1a neurons; anterior-posterior subdivision of organism; brain; embryonic central brain neurons; and larval neurons. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nplp1 in Genome Data Viewer
Location:
60F1-60F1; 2-107 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (25032377..25040377)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20919900..20927900)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene zipper Neighboring gene unzipped Neighboring gene gooseberry-neuro Neighboring gene gooseberry

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of a novel neuropeptide, NVGTLARDFQLPIPNamide, in the larval and adult brain of Drosophila melanogaster. Verleyen P, et al. J Neurochem, 2004 Jan. PMID 14690519
  2. Combinatorial coding for Drosophila neurons. Jones R. PLoS Biol, 2007 Feb. PMID 20076660, Free PMC Article
  3. Peptidomics of CNS-associated neurohemal systems of adult Drosophila melanogaster: a mass spectrometric survey of peptides from individual flies. Predel R, et al. J Comp Neurol, 2004 Jun 28. PMID 15174081
  4. Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes. Shafer OT, et al. J Comp Neurol, 2006 Sep 10. PMID 16856134, Free PMC Article
  5. Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits. Carlsson MA, et al. J Comp Neurol, 2010 Aug 15. PMID 20575072

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nplp1 neuropeptide neurons in the developing Drosophila nerve cord belong to two sub-classes; Tv1 and dAp neurons, generated by two distinct progenitors. Nplp1 neurons are specified by spatial cues
    Title: Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide hormone activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables receptor ligand activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular space IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Neuropeptide-like precursor 1
Names
APK peptide
CG3441-PA
CG3441-PB
CG3441-PC
IPNamide
IPNamide peptide
MTYamide peptide
Nplp1-PA
Nplp1-PB
Nplp1-PC
neuropeptide like precursor 1
neuropeptide like precursor protein 1
neuropeptide-like precursor 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    25032377..25040377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144288.2 → NP_001137760.1  Neuropeptide-like precursor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137760.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZQ9

  2. NM_001043105.3 → NP_001036570.1  Neuropeptide-like precursor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8W0

  3. NM_138149.3 → NP_611993.1  Neuropeptide-like precursor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95T41, Q9W0W6
    Related
    FBpp0072348
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7YZQ9 B7YZQ9
Q0E8W0 Q0E8W0
Q9W0W6.2 Q9W0W6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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