U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

p130CAS p130CAS [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38021, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
p130CASprovided by FlyBase
Official Full Name
p130CASprovided by FlyBase
Primary source
FLYBASE:FBgn0035101
Locus tag
Dmel_CG1212
See related
AllianceGenome:FB:FBgn0035101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1212; CT1293; Dcas; DCas; Dmel\CG1212; p130cas; p130Cas
Summary
Involved in axonal defasciculation; cell-cell adhesion; and maintenance of cell polarity. Predicted to be located in focal adhesion. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Is expressed in several structures, including amnioserosa anlage; amnioserosa primordium; dorsal ectoderm; dorsal thoracic disc; and ventral nerve cord. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to several human genes including BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See p130CAS in Genome Data Viewer
Location:
61B1-61B2; 3-1 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (152884..174517)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (152884..174517)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dynein intermediate chain at 61B Neighboring gene long non-coding RNA:CR43151 Neighboring gene antisense RNA:CR45806 Neighboring gene uncharacterized protein Neighboring gene Vitamin D[[3]] up-regulated protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis. Camacho Leal Mdel P, et al. Gene, 2015 May 10. PMID 25727852, Free PMC Article
  2. Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development. Huang Z, et al. Development, 2007 Jun. PMID 17537798
  3. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Dourlen P, et al. Mol Psychiatry, 2017 Jun. PMID 27113998, Free PMC Article
  4. Induction of focal adhesions and motility in Drosophila S2 cells. Ribeiro SA, et al. Mol Biol Cell, 2014 Dec 1. PMID 25273555, Free PMC Article
  5. Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. Dourlen P, et al. Curr Genet Med Rep, 2018. PMID 30147999, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCAR1 has a pivotal role in the regulation of tissue homeostasis and morphogeneis. (Review)
    Title: p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis.
  2. p130CAS signaling protein functions with integrins to specify axon guidance during development.
    Title: Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 164030-164149 mobile_element_type = transposon:INE-1{}3913

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in axonal defasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
p130CAS
Names
CG1212-PB
CG1212-PD
CG1212-PE
CG1212-PF
CG1212-PG
p130CAS-PB
p130CAS-PD
p130CAS-PE
p130CAS-PF
p130CAS-PG

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    152884..174517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103986.3 → NP_001097456.2  p130CAS, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097456.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4IJ58, A8JNG5
    Conserved Domains (3) summary
    cd11549
    Location:434 → 596
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
    cd11844
    Location:81 → 136
    SH3_CAS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding proteins
    pfam12026
    Location:612 → 817
    DUF3513; Domain of unknown function (DUF3513)

  2. NM_001169831.3 → NP_001163302.1  p130CAS, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163302.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVE5
    Conserved Domains (3) summary
    cd11549
    Location:396 → 558
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
    cd11844
    Location:43 → 98
    SH3_CAS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding proteins
    pfam12026
    Location:574 → 779
    DUF3513; Domain of unknown function (DUF3513)

  3. NM_167797.3 → NP_728478.1  p130CAS, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728478.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U71, Q9W0U7, Q9W0U8
    Related
    FBpp0072377
    Conserved Domains (2) summary
    cd11549
    Location:171 → 333
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
    pfam12026
    Location:349 → 554
    DUF3513; Domain of unknown function (DUF3513)

  4. NM_001144389.2 → NP_001137861.1  p130CAS, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137861.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U71, Q9W0U7, Q9W0U8
    Conserved Domains (2) summary
    cd11549
    Location:171 → 333
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
    pfam12026
    Location:349 → 554
    DUF3513; Domain of unknown function (DUF3513)

  5. NM_001144388.2 → NP_001137860.1  p130CAS, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0H1
    Conserved Domains (2) summary
    cd11549
    Location:170 → 332
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
    pfam12026
    Location:348 → 553
    DUF3513; Domain of unknown function (DUF3513)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4IJ58 A4IJ58
B7Z0H1 B7Z0H1
Q7KVE5 Q7KVE5
Q95U71 Q95U71

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous