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thoc7 thoc7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38033, updated on 9-Dec-2024

Summary

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Official Symbol
thoc7provided by FlyBase
Official Full Name
thoc7provided by FlyBase
Primary source
FLYBASE:FBgn0035110
Locus tag
Dmel_CG17143
See related
AllianceGenome:FB:FBgn0035110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17143; Dmel\CG17143; Thoc7; THOC7
Summary
Predicted to be involved in mRNA export from nucleus. Located in nucleus. Part of THO complex. Is expressed in adult head; egg chamber; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human THOC7 (THO complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See thoc7 in Genome Data Viewer
Location:
61B2-61B2; 3-1 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (211636..212687, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (211636..212687, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glycerol kinase 1 Neighboring gene Nitrilase and fragile histidine triad fusion protein Neighboring gene uncharacterized protein Neighboring gene Pre-mRNA processing factor 4 kinase Neighboring gene Dis3 like 3'-5' exoribonuclease 2 Neighboring gene pseudo Neighboring gene Kaz1-ORFB

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. p53 and PI3K/AKT signalings are up-regulated in flies with defects in the THO complex. Moon S, et al. Mol Cells, 2013 Mar. PMID 23475424, Free PMC Article
  2. piRNA-independent transposon silencing by the Drosophila THO complex. Zhang G, et al. Dev Cell, 2021 Sep 27. PMID 34547226, Free PMC Article
  3. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
  4. Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. Kopytova DV, et al. Genes Dev, 2010 Jan 1. PMID 20048002, Free PMC Article
  5. Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila. Hur JK, et al. Genes Dev, 2016 Apr 1. PMID 27036967, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus in response to heat stress IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex part of transcription export complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription export complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
thoc7
Names
CG17143-PA
CG17143-PB
thoc7-PA
thoc7-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    211636..212687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138167.1 → NP_612011.1  thoc7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612011.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRJ8
    Related
    FBpp0072426, FBtr0072527
    Conserved Domains (1) summary
    pfam05615
    Location:23 → 151
    THOC7; Tho complex subunit 7

  2. NM_167804.2 → NP_728489.2  thoc7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728489.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1WWD6, Q8IRJ8, Q9W0T8
    Conserved Domains (1) summary
    pfam05615
    Location:24 → 152
    THOC7; Tho complex subunit 7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IRJ8.2 Q8IRJ8

Gene LinkOut

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