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CG1233 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38063, updated on 9-Dec-2024

Summary

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Official Symbol
CG1233provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035137
Locus tag
Dmel_CG1233
See related
AllianceGenome:FB:FBgn0035137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1233
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human ZNF316 (zinc finger protein 316) and ZNF787 (zinc finger protein 787). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG1233 in Genome Data Viewer
Location:
61C1-61C1; 3-0.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (361472..365681)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (361472..365681)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Regulator of cullins 1b Neighboring gene Cell division cycle 5 Neighboring gene uncharacterized protein Neighboring gene trachealess Neighboring gene long non-coding RNA:CR45378 Neighboring gene long non-coding RNA:CR43969

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7. Zahoor MK, et al. Mol Genet Genomics, 2019 Jun. PMID 30656413
  2. Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. Rehwinkel J, et al. RNA, 2005 Oct. PMID 16199763, Free PMC Article
  3. A Comprehensive Drosophila melanogaster Transcription Factor Interactome. Shokri L, et al. Cell Rep, 2019 Apr 16. PMID 30995488, Free PMC Article
  4. A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development. Schertel C, et al. Genome Res, 2015 Apr. PMID 25568052, Free PMC Article
  5. Transcription factor networks in Drosophila melanogaster. Rhee DY, et al. Cell Rep, 2014 Sep 25. PMID 25242320, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1233-PA
CG1233-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    361472..365681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167833.2 → NP_728528.1  uncharacterized protein Dmel_CG1233, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728528.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0Q9
    Related
    FBpp0072448
    Conserved Domains (5) summary
    COG1594
    Location:778 → 873
    RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
    sd00017
    Location:702 → 722
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:700 → 722
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:705 → 811
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:687 → 711
    zf-H2C2_2; Zinc-finger double domain

  2. NM_138190.2 → NP_612034.1  uncharacterized protein Dmel_CG1233, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612034.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP52, Q9I7U7
    Related
    FBpp0072447
    Conserved Domains (5) summary
    COG1594
    Location:966 → 1061
    RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
    sd00017
    Location:890 → 910
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:888 → 910
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:893 → 999
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:875 → 899
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I7U7 Q9I7U7
Q9W0Q9 Q9W0Q9

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