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ebd1 earthbound 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38082, updated on 9-Dec-2024

Summary

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Official Symbol
ebd1provided by FlyBase
Official Full Name
earthbound 1provided by FlyBase
Primary source
FLYBASE:FBgn0035153
Locus tag
Dmel_CG3371
See related
AllianceGenome:FB:FBgn0035153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3371; Dmel\CG3371; Ebd; Ebd1; EP3592
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in adult somatic muscle development; positive regulation of canonical Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; mesoderm; salivary gland; and somatic muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ebd1 in Genome Data Viewer
Location:
61C8-61C8; 3-0.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (682885..685549, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (682885..685549, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene highroad Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation. Huang J, et al. EMBO Rep, 2021 Apr 7. PMID 33565211, Free PMC Article
  2. A fly's eye view of quiescent neural stem cells. Gujar MR, et al. Oxf Open Neurosci, 2022. PMID 38596705, Free PMC Article
  3. Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective. Tian A, et al. J Dev Biol, 2018 Mar 28. PMID 29615557, Free PMC Article
  4. Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin. Xin N, et al. Development, 2011 Nov. PMID 22028028, Free PMC Article
  5. High-resolution in situ hybridization analysis on the chromosomal interval 61C7-61C8 of Drosophila melanogaster reveals interbands as open chromatin domains. Zielke T, et al. Chromosoma, 2016 Jun. PMID 26520107

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
earthbound 1
Names
CG3371-PA
earthbound
ebd1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    682885..685549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138206.2 → NP_612050.1  earthbound 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612050.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0N9
    Related
    FBpp0072506
    Conserved Domains (2) summary
    smart00674
    Location:158 → 224
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    cl21459
    Location:90 → 138
    HTH; Helix-turn-helix domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W0N9 Q9W0N9

Gene LinkOut

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