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Tbc1d22b TBC1 domain family, member 22B [ Mus musculus (house mouse) ]

Gene ID: 381085, updated on 27-Nov-2024

Summary

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Official Symbol
Tbc1d22bprovided by MGI
Official Full Name
TBC1 domain family, member 22Bprovided by MGI
Primary source
MGI:MGI:2681867
See related
Ensembl:ENSMUSG00000042203 AllianceGenome:MGI:2681867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable 14-3-3 protein binding activity and GTPase activator activity. Predicted to be active in Golgi apparatus. Orthologous to human TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 16.0), adrenal adult (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tbc1d22b in Genome Data Viewer
Location:
17 A3.3; 17 15.43 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29768765..29825868)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29549768..29606895)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26885 Neighboring gene STARR-positive B cell enhancer ABC_E8946 Neighboring gene STARR-positive B cell enhancer ABC_E9949 Neighboring gene proviral integration site 1 Neighboring gene transmembrane 217B Neighboring gene transmembrane protein 217 Neighboring gene STARR-seq mESC enhancer starr_42293 Neighboring gene TBC1 domain family, member 22B, opposite strand Neighboring gene microRNA 7667 Neighboring gene STARR-positive B cell enhancer ABC_E7509 Neighboring gene predicted gene, 28043 Neighboring gene ring finger protein 8 Neighboring gene predicted gene, 20161

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel genes differentially expressed in cortical regions during late neurogenesis. Mühlfriedel S, et al. Eur J Neurosci, 2007 Jul. PMID 17614941
  2. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif BA, et al. J Proteome Res, 2006 Sep. PMID 16944949
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31516, MGC61359

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TBC1 domain family member 22B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414341.1 → NP_001401270.1  TBC1 domain family member 22B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163629

  2. NM_001414343.1 → NP_001401272.1  TBC1 domain family member 22B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163629

  3. NM_001414346.1 → NP_001401275.1  TBC1 domain family member 22B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163629

  4. NM_198647.2 → NP_941049.1  TBC1 domain family member 22B isoform 1

    See identical proteins and their annotated locations for NP_941049.1

    Status: VALIDATED

    Source sequence(s)
    AC163629
    Consensus CDS
    CCDS28597.1
    UniProtKB/TrEMBL
    Q80VE5
    Related
    ENSMUSP00000046877.8, ENSMUST00000048677.9
    Conserved Domains (1) summary
    smart00164
    Location:207 → 457
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RNA

  1. NR_182277.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163629

  2. NR_182287.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163629
    Related
    ENSMUST00000234778.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29768765..29825868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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