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Rmdn2 regulator of microtubule dynamics 2 [ Mus musculus (house mouse) ]

Gene ID: 381110, updated on 27-Nov-2024

Summary

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Official Symbol
Rmdn2provided by MGI
Official Full Name
regulator of microtubule dynamics 2provided by MGI
Primary source
MGI:MGI:2147043
See related
Ensembl:ENSMUSG00000036368 AllianceGenome:MGI:2147043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RMD-2; mRMD-2; Fam82a1
Summary
Predicted to enable microtubule binding activity. Located in mitochondrion. Is expressed in adrenal gland; anal canal; glans of male genital tubercle; hindgut; and testis. Orthologous to human RMDN2 (regulator of microtubule dynamics 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 4.0), adrenal adult (RPKM 1.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Rmdn2 in Genome Data Viewer
Location:
17 E3; 17 50.3 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79886025..80000630)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (79578596..79684976)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10494 Neighboring gene mps one binder kinase activator-like 2B pseudogene Neighboring gene STARR-seq mESC enhancer starr_43284 Neighboring gene STARR-seq mESC enhancer starr_43286 Neighboring gene predicted gene, 33006 Neighboring gene predicted gene, 53962 Neighboring gene Cyp1b1 5' regulatory region Neighboring gene cytochrome P450, family 1, subfamily b, polypeptide 1 Neighboring gene predicted gene, 41624

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. Oishi K, et al. J Cell Biol, 2007 Dec 17. PMID 18070910, Free PMC Article
  2. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC37733

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle pole IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulator of microtubule dynamics protein 2
Names
family with sequence similarity 82, member A1
microtubule-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368309.2 → NP_001355238.1  regulator of microtubule dynamics protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132612

  2. NM_001368310.1 → NP_001355239.1  regulator of microtubule dynamics protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132612

  3. NM_001368311.1 → NP_001355240.1  regulator of microtubule dynamics protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132612

  4. NM_001368312.1 → NP_001355241.1  regulator of microtubule dynamics protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132612
    Conserved Domains (1) summary
    cl30292
    Location:341 → 410
    PRK15331; type III secretion system translocator chaperone SicA

  5. NM_001368313.2 → NP_001355242.1  regulator of microtubule dynamics protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC132612

  6. NM_001368314.2 → NP_001355243.1  regulator of microtubule dynamics protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132612
    Consensus CDS
    CCDS28985.1
    UniProtKB/Swiss-Prot
    A9UN02, Q8BSE0, Q8CIF1
    Related
    ENSMUSP00000153443.2, ENSMUST00000225357.2

  7. NM_001414401.1 → NP_001401330.1  regulator of microtubule dynamics protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132612
    UniProtKB/Swiss-Prot
    A9UN02, Q8BSE0, Q8CIF1

  8. NM_001414402.1 → NP_001401331.1  regulator of microtubule dynamics protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC132612

  9. NM_001414403.1 → NP_001401332.1  regulator of microtubule dynamics protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC132612

  10. NM_001414404.1 → NP_001401333.1  regulator of microtubule dynamics protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC132612

  11. NM_001414405.1 → NP_001401334.1  regulator of microtubule dynamics protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC132612

  12. NM_001414406.1 → NP_001401335.1  regulator of microtubule dynamics protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC132612

  13. NM_001414407.1 → NP_001401336.1  regulator of microtubule dynamics protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC132612

  14. NM_001414408.1 → NP_001401337.1  regulator of microtubule dynamics protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132612

  15. NM_201361.3 → NP_958749.1  regulator of microtubule dynamics protein 2 isoform 1

    See identical proteins and their annotated locations for NP_958749.1

    Status: VALIDATED

    Source sequence(s)
    AC132612
    Consensus CDS
    CCDS28985.1
    UniProtKB/Swiss-Prot
    A9UN02, Q8BSE0, Q8CIF1
    Related
    ENSMUSP00000044543.3, ENSMUST00000040368.3
    Conserved Domains (1) summary
    TIGR02552
    Location:341 → 410
    LcrH_SycD; type III secretion low calcium response chaperone LcrH/SycD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    79886025..80000630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524498.3 → XP_006524561.1  regulator of microtubule dynamics protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006524561.1

    Conserved Domains (1) summary
    sd00006
    Location:608 → 658
    TPR; TPR repeat [structural motif]

  2. XM_006524499.4 → XP_006524562.1  regulator of microtubule dynamics protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006524562.1

    Conserved Domains (1) summary
    sd00006
    Location:608 → 658
    TPR; TPR repeat [structural motif]

  3. XM_006524497.1 → XP_006524560.1  regulator of microtubule dynamics protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006524560.1

    Conserved Domains (1) summary
    sd00006
    Location:608 → 658
    TPR; TPR repeat [structural motif]

  4. XM_006524507.1 → XP_006524570.1  regulator of microtubule dynamics protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006524570.1

  5. XM_006524502.4 → XP_006524565.1  regulator of microtubule dynamics protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006524565.1

  6. XM_006524501.4 → XP_006524564.1  regulator of microtubule dynamics protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006524564.1

  7. XM_006524503.5 → XP_006524566.1  regulator of microtubule dynamics protein 2 isoform X3

  8. XM_006524496.5 → XP_006524559.1  regulator of microtubule dynamics protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006524559.1

    Conserved Domains (1) summary
    sd00006
    Location:608 → 658
    TPR; TPR repeat [structural motif]

  9. XM_036160671.1 → XP_036016564.1  regulator of microtubule dynamics protein 2 isoform X1

    Conserved Domains (1) summary
    sd00006
    Location:608 → 658
    TPR; TPR repeat [structural motif]

  10. XM_036160673.1 → XP_036016566.1  regulator of microtubule dynamics protein 2 isoform X4

    Conserved Domains (1) summary
    cl30292
    Location:341 → 410
    PRK15331; type III secretion system translocator chaperone SicA

  11. XM_030249874.1 → XP_030105734.1  regulator of microtubule dynamics protein 2 isoform X6

    Conserved Domains (1) summary
    cl30292
    Location:145 → 214
    PRK15331; type III secretion system translocator chaperone SicA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSE0.1 GenPept UniProtKB/Swiss-Prot:Q8BSE0

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