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Prob1 proline rich basic protein 1 [ Mus musculus (house mouse) ]

Gene ID: 381148, updated on 27-Nov-2024

Summary

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Official Symbol
Prob1provided by MGI
Official Full Name
proline rich basic protein 1provided by MGI
Primary source
MGI:MGI:2686460
See related
Ensembl:ENSMUSG00000073600 AllianceGenome:MGI:2686460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1614
Summary
Predicted to be active in nucleoplasm. Is expressed in Meckel's cartilage and skeleton. Orthologous to human PROB1 (proline rich basic protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Prob1 in Genome Data Viewer
Location:
18 B2; 18 19.2 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35783400..35788274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35650347..35655221, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene polyadenylate-binding protein-interacting protein 2 Neighboring gene solute carrier family 23 (nucleobase transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_44241 Neighboring gene STARR-seq mESC enhancer starr_44242 Neighboring gene marginal zone B and B1 cell-specific protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7578 Neighboring gene spermatogenesis associated 24 Neighboring gene DnaJ heat shock protein family (Hsp40) member C18 Neighboring gene STARR-seq mESC enhancer starr_44246

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. Goldbraikh D, et al. EMBO Rep, 2020 Apr 3. PMID 32133736, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proline-rich basic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270646.2 → NP_001257575.1  proline-rich basic protein 1

    Status: VALIDATED

    Source sequence(s)
    AC121821, AK146021
    Consensus CDS
    CCDS79611.1
    UniProtKB/TrEMBL
    A0A087WR45, Q3UKG2
    Related
    ENSMUSP00000140465.2, ENSMUST00000190196.5
    Conserved Domains (1) summary
    pfam15232
    Location:866 → 935
    DUF4585; Domain of unknown function (DUF4585)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35783400..35788274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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