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LysB Lysozyme B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38125, updated on 4-Jan-2025

Summary

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Official Symbol
LysBprovided by FlyBase
Official Full Name
Lysozyme Bprovided by FlyBase
Primary source
FLYBASE:FBgn0004425
Locus tag
Dmel_CG1179
See related
AllianceGenome:FB:FBgn0004425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1179; Dmel\CG1179; Lys B; lysB
Summary
Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Is expressed in adult midgut and embryonic/larval midgut. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See LysB in Genome Data Viewer
Location:
61F3-61F3; 3-0 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1207371..1207981)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1207371..1207981)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene multiple wing hairs Neighboring gene meep Neighboring gene uncharacterized protein Neighboring gene Lysozyme C Neighboring gene Lysozyme D Neighboring gene Lysozyme E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress. Ma D, et al. iScience, 2019 Sep 27. PMID 31422284, Free PMC Article
  2. The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract. Daffre S, et al. Mol Gen Genet, 1994 Jan. PMID 8159165
  3. Insect lysozymes. Hultmark D. EXS, 1996. PMID 8765296
  4. Molecular adaptation of Drosophila melanogaster lysozymes to a digestive function. Regel R, et al. Insect Biochem Mol Biol, 1998 May-Jun. PMID 9692234
  5. Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. Sala A, et al. EMBO J, 2011 May 4. PMID 21448136, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
  
enables lysozyme activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lysozyme B
Names
CG1179-PA
CG1179-PB
LysB-PA
LysB-PB
lyzozyme B
NP_001261245.1
NP_523882.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1207371..1207981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274316.1 → NP_001261245.1  lysozyme B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261245.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P37158, Q08694, Q9W0J8
    UniProtKB/TrEMBL
    D3PFG8
    Conserved Domains (1) summary
    pfam00062
    Location:19 → 139
    Lys; C-type lysozyme/alpha-lactalbumin family

  2. NM_079158.3 → NP_523882.1  lysozyme B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523882.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P37158, Q08694, Q9W0J8
    UniProtKB/TrEMBL
    D3PFG8
    Related
    FBpp0072524
    Conserved Domains (1) summary
    pfam00062
    Location:19 → 139
    Lys; C-type lysozyme/alpha-lactalbumin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3PFG8 D3PFG8
Q08694.2 Q08694

Gene LinkOut

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