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galene galene [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38133, updated on 4-Jan-2025

Summary

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Official Symbol
galeneprovided by FlyBase
Official Full Name
galeneprovided by FlyBase
Primary source
FLYBASE:FBgn0035192
Locus tag
Dmel_CG9194
See related
AllianceGenome:FB:FBgn0035192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0109301.19; anon-WO0109301.20; anon-WO0109301.21; anon-WO0109301.22; anon-WO0109301.23; anon-WO0109301.24; anon-WO0109301.25; anon-WO0109301.26; anon-WO0109301.27; anon-WO0109301.28; anon-WO0109301.29; anon-WO0109301.3; anon-WO0109301.31; anon-WO0109301.32; anon-WO0109301.33; anon-WO0109301.34; anon-WO0109301.36; anon-WO0109301.37; anon-WO0109301.38; C9194; CG9194; Dmel\CG9194
Summary
Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in dorsal pharyngeal muscle cell; larval muscle system; and larval somatic muscle cell. Used to study heart conduction disease. Orthologous to human KCNK7 (potassium two pore domain channel subfamily K member 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See galene in Genome Data Viewer
Location:
61F4-61F4; 3-0 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1235726..1242025)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1235726..1242025)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45747 Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 61F Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Age-dependent diastolic heart failure in an in vivo Drosophila model. Klassen MP, et al. Elife, 2017 Mar 22. PMID 28328397, Free PMC Article
  2. Novel Drosophila two-pore domain K channels: rescue of channel function by heteromeric assembly. Döring F, et al. Eur J Neurosci, 2006 Oct. PMID 17074048
  3. Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster. Wei HC, et al. Genome, 2003 Dec. PMID 14663523
  4. Operation of a homeostatic sleep switch. Pimentel D, et al. Nature, 2016 Aug 18. PMID 27487216, Free PMC Article
  5. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. Wilczynski B, et al. PLoS Comput Biol, 2012. PMID 23236268, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
galene
Names
CG9194-PA
galene-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1235726..1242025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138240.2 → NP_612084.1  galene [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NR05, Q9W0J0
    Related
    FBpp0072545
    Conserved Domains (3) summary
    pfam06390
    Location:341 → 586
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    pfam00520
    Location:621 → 709
    Ion_trans; Ion transport protein
    pfam07885
    Location:134 → 189
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NR05 Q6NR05
Q9W0J0 Q9W0J0

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