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Acat2 Acetyl-CoA acetyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38147, updated on 4-Jan-2025

Summary

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Official Symbol
Acat2provided by FlyBase
Official Full Name
Acetyl-CoA acetyltransferase 2provided by FlyBase
Primary source
FLYBASE:FBgn0035203
Locus tag
Dmel_CG9149
See related
AllianceGenome:FB:FBgn0035203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACAA1; ACAT; ACAT2; CG9149; Dmel\CG9149
Summary
Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in peroxisome. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Acat2 in Genome Data Viewer
Location:
61F5-61F5; 3-0 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1302944..1304717)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1302944..1304717)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene supercoiling factor Neighboring gene Rac1 Neighboring gene 5' nucleotidase A Neighboring gene Ctr9 Neighboring gene sturkopf

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster. Wei HC, et al. Genome, 2003 Dec. PMID 14663523
  2. The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. Ashton-Beaucage D, et al. Cell, 2010 Oct 15. PMID 20946983
  3. Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse. Song T, et al. Cell Res, 2023 Jun. PMID 37055592, Free PMC Article
  4. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277
  5. Drosophila mRNA Localization During Later Development: Past, Present, and Future. Hughes SC, et al. Front Genet, 2019. PMID 30899273, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Acetyl-CoA acetyltransferase 2
Names
Acat2-PA
B-ketoacyl-CoA thiolase
CG9149-PA
NP_612094.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1302944..1304717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138250.3 → NP_612094.2  Acetyl-CoA acetyltransferase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612094.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0H6, T1W0I3
    Related
    FBpp0072560
    Conserved Domains (2) summary
    PRK05790
    Location:1 → 391
    PRK05790; putative acyltransferase; Provisional
    cd00751
    Location:5 → 390
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXL6 Q8SXL6
Q9W0H6 Q9W0H6

Gene LinkOut

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