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Nt5a 5' nucleotidase A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38148, updated on 4-Jan-2025

Summary

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Official Symbol
Nt5aprovided by FlyBase
Official Full Name
5' nucleotidase Aprovided by FlyBase
Primary source
FLYBASE:FBgn0035204
Locus tag
Dmel_CG2277
See related
AllianceGenome:FB:FBgn0035204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
28575006; CG2277; Dmel\CG2277; dNT5A
Summary
Predicted to enable 5'-nucleotidase activity. Is expressed in organism. Orthologous to human NT5DC1 (5'-nucleotidase domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Nt5a in Genome Data Viewer
Location:
61F5-61F5; 3-0 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1304850..1307418, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1304850..1307418, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rac1 Neighboring gene Acetyl-CoA acetyltransferase 2 Neighboring gene Ctr9 Neighboring gene sturkopf Neighboring gene HECT and RLD domain containing E3 ubiquitin ligase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigating cytosolic 5'-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr). Singgih EL, et al. Transl Psychiatry, 2021 Jan 18. PMID 33462198, Free PMC Article
  2. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. Litovchenko M, et al. Sci Adv, 2021 Jan. PMID 33514540, Free PMC Article
  3. The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. Pogson JH, et al. PLoS Genet, 2014 Nov. PMID 25412178, Free PMC Article
  4. A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting. Mindorff EN, et al. Genetics, 2007 Aug. PMID 17603113, Free PMC Article
  5. Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Blanco E, et al. Genome Biol, 2008. PMID 18783608, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
5' nucleotidase A
Names
CG2277-PA
CG2277-PB
CG2277-PC
Nt5a-PA
Nt5a-PB
Nt5a-PC
NP_001261248.1
NP_001286897.1
NP_612095.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1304850..1307418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274319.1 → NP_001261248.1  5' nucleotidase A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261248.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961B3, Q9W0H5
    Conserved Domains (1) summary
    TIGR02244
    Location:101 → 466
    HAD-IG-Ncltidse; HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase

  2. NM_138251.3 → NP_612095.3  5' nucleotidase A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612095.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961B3, Q9W0H5
    Related
    FBpp0072613
    Conserved Domains (1) summary
    TIGR02244
    Location:101 → 466
    HAD-IG-Ncltidse; HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase

  3. NM_001299968.1 → NP_001286897.1  5' nucleotidase A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCB6
    Conserved Domains (1) summary
    cl17687
    Location:2 → 367
    5_nucleotid; 5' nucleotidase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961B3 Q961B3
X2JCB6 X2JCB6

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