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Tmem240 transmembrane protein 240 [ Mus musculus (house mouse) ]

Gene ID: 381582, updated on 4-Jan-2025

Summary

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Official Symbol
Tmem240provided by MGI
Official Full Name
transmembrane protein 240provided by MGI
Primary source
MGI:MGI:3648074
See related
Ensembl:ENSMUSG00000084845 AllianceGenome:MGI:3648074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm5151; EG381582
Summary
Located in TMEM240-body and synaptic membrane. Is active in cerebellar climbing fiber to Purkinje cell synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 21. Orthologous to human TMEM240 (transmembrane protein 240). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cerebellum adult (RPKM 12.9), cortex adult (RPKM 7.0) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem240 in Genome Data Viewer
Location:
4 E2; 4 87.18 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155818336..155825025)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155734804..155740564)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene fibronectin type III domain containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E6297 Neighboring gene STARR-seq mESC enhancer starr_12272 Neighboring gene Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) Neighboring gene STARR-seq mESC enhancer starr_12273 Neighboring gene predicted gene, 22573 Neighboring gene RIKEN cDNA 1500002C15 gene Neighboring gene ATPase family, AAA domain containing 3A Neighboring gene STARR-positive B cell enhancer ABC_E4739 Neighboring gene ATPase family, AAA domain containing 3A, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals. Homa M, et al. Cerebellum, 2020 Jun. PMID 32002801
  2. Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Trinidad JC, et al. Mol Cell Proteomics, 2012 Aug. PMID 22645316, Free PMC Article
  3. Neural-specific distribution of transmembrane protein TMEM240 and formation of TMEM240-Body. Hu Q, et al. Int J Biol Macromol, 2020 Oct 15. PMID 32535204
  4. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Khang R, et al. Sci Rep, 2021 Nov 23. PMID 34815492, Free PMC Article
  5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neural-specific distribution of transmembrane protein TMEM240 and formation of TMEM240-Body.
    Title: Neural-specific distribution of transmembrane protein TMEM240 and formation of TMEM240-Body.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in TMEM240-body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cerebellar climbing fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 240

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101506.1 → NP_001094976.1  transmembrane protein 240

    See identical proteins and their annotated locations for NP_001094976.1

    Status: VALIDATED

    Source sequence(s)
    AL670236, AU255417, BY725301, CJ116478, CJ257322
    Consensus CDS
    CCDS51403.1
    UniProtKB/Swiss-Prot
    B2RWJ3
    Related
    ENSMUSP00000127341.3, ENSMUST00000127188.3
    Conserved Domains (1) summary
    pfam15207
    Location:1 → 173
    TMEM240; TMEM240 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155818336..155825025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164215.1 → XP_036020108.1  transmembrane protein 240 isoform X3

    Conserved Domains (1) summary
    pfam15207
    Location:158 → 212
    TMEM240; TMEM240 family

  2. XM_036164213.1 → XP_036020106.1  transmembrane protein 240 isoform X1

    Conserved Domains (1) summary
    pfam15207
    Location:158 → 338
    TMEM240; TMEM240 family

  3. XM_036164214.1 → XP_036020107.1  transmembrane protein 240 isoform X2

    Conserved Domains (1) summary
    pfam15207
    Location:158 → 212
    TMEM240; TMEM240 family

  4. XM_036164217.1 → XP_036020110.1  transmembrane protein 240 isoform X5

    Conserved Domains (1) summary
    pfam15207
    Location:158 → 212
    TMEM240; TMEM240 family

  5. XM_036164216.1 → XP_036020109.1  transmembrane protein 240 isoform X4

    Conserved Domains (1) summary
    pfam15207
    Location:158 → 212
    TMEM240; TMEM240 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RWJ3.1 GenPept UniProtKB/Swiss-Prot:B2RWJ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials