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Plpp4 phospholipid phosphatase 4 [ Mus musculus (house mouse) ]

Gene ID: 381925, updated on 4-Jan-2025

Summary

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Official Symbol
Plpp4provided by MGI
Official Full Name
phospholipid phosphatase 4provided by MGI
Primary source
MGI:MGI:2685936
See related
Ensembl:ENSMUSG00000070366 AllianceGenome:MGI:2685936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1090; Ppapdc1a; C030048B12Rik
Summary
Predicted to enable diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Acts upstream of or within blastocyst hatching. Predicted to be active in membrane. Is expressed in early conceptus and secondary oocyte. Orthologous to human PLPP4 (phospholipid phosphatase 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cerebellum adult (RPKM 3.6), CNS E18 (RPKM 3.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Plpp4 in Genome Data Viewer
Location:
7 F3; 7 71.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128858114..128993138)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (129256390..129391412)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Rho family GTPase 2 pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_20220 Neighboring gene STARR-seq mESC enhancer starr_20221 Neighboring gene STARR-seq mESC enhancer starr_20222 Neighboring gene STARR-seq mESC enhancer starr_20226 Neighboring gene predicted gene, 33027 Neighboring gene STARR-seq mESC enhancer starr_20231 Neighboring gene STARR-seq mESC enhancer starr_20232 Neighboring gene STARR-seq mESC enhancer starr_20233 Neighboring gene STARR-seq mESC enhancer starr_20234 Neighboring gene STARR-positive B cell enhancer mm9_chr7:136735231-136735532 Neighboring gene WD repeat domain 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables diacylglycerol diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables diacylglycerol diphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion import ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipid phosphatase 4
Names
phosphatidate phosphatase PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
phosphatidic acid phosphatase type 2 domain-containing protein 1A
NP_001074432.1
NP_001406315.1
NP_001406316.1
NP_001406317.1
NP_001406318.1
NP_001406319.1
NP_001406320.1
XP_017177812.1
XP_030098589.1
XP_036009094.1
XP_036009096.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080963.2 → NP_001074432.1  phospholipid phosphatase 4 isoform 1

    See identical proteins and their annotated locations for NP_001074432.1

    Status: VALIDATED

    Source sequence(s)
    AC100956, AC109182
    Consensus CDS
    CCDS40154.1
    UniProtKB/Swiss-Prot
    Q0VBU9
    Related
    ENSMUSP00000091557.5, ENSMUST00000094018.6
    Conserved Domains (1) summary
    cd03390
    Location:37 → 225
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  2. NM_001419386.1 → NP_001406315.1  phospholipid phosphatase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100956, AC109182

  3. NM_001419387.1 → NP_001406316.1  phospholipid phosphatase 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC100956, AC109182

  4. NM_001419388.1 → NP_001406317.1  phospholipid phosphatase 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC100956, AC109182

  5. NM_001419389.1 → NP_001406318.1  phospholipid phosphatase 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC100956, AC109182

  6. NM_001419390.1 → NP_001406319.1  phospholipid phosphatase 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC100956, AC109182

  7. NM_001419391.1 → NP_001406320.1  phospholipid phosphatase 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC100956, AC109182

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    128858114..128993138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322323.3 → XP_017177812.1  phospholipid phosphatase 4 isoform X1

    Conserved Domains (1) summary
    cd03390
    Location:37 → 224
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  2. XM_036153203.1 → XP_036009096.1  phospholipid phosphatase 4 isoform X5

    Conserved Domains (1) summary
    cl00474
    Location:37 → 167
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  3. XM_030242729.2 → XP_030098589.1  phospholipid phosphatase 4 isoform X7

    Conserved Domains (1) summary
    cd03390
    Location:7 → 104
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  4. XM_036153201.1 → XP_036009094.1  phospholipid phosphatase 4 isoform X3

    Conserved Domains (1) summary
    cd03390
    Location:1 → 171
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VBU9.1 GenPept UniProtKB/Swiss-Prot:Q0VBU9

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