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GC gamma-glutamyl carboxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38194, updated on 4-Jan-2025

Summary

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Official Symbol
GCprovided by FlyBase
Official Full Name
gamma-glutamyl carboxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0035245
Locus tag
Dmel_CG13927
See related
AllianceGenome:FB:FBgn0035245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13927; dgammaC; DgammaC; dGC; Dmel\CG13927; gammaC
Summary
Enables gamma-glutamyl carboxylase activity. Predicted to be involved in vitamin K metabolic process. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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Location:
62A9-62A9; 3-0.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1623179..1629301, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1623179..1629301, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45814 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ATP binding cassette subfamily B member 7 Neighboring gene uncharacterized protein Neighboring gene neuronal Synaptobrevin Neighboring gene Methyltransferase like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila. Walker CS, et al. J Biol Chem, 2001 Mar 16. PMID 11110799
  2. Biochemical characterization of Drosophila gamma-glutamyl carboxylase and its role in fly development. Bandyopadhyay PK, et al. Insect Mol Biol, 2006 Apr. PMID 16640725
  3. Improvement of the recombinant human coagulation factor IX expression by co-expression of a novel transcript of Drosophila γ carboxylase in a human cell line. Moniri Javadhesari S, et al. Biotechnol Lett, 2020 Nov. PMID 32514789
  4. Expression of biologically active human clotting factor IX in Drosophila S2 cells: γ-carboxylation of a human vitamin K-dependent protein by the insect enzyme. Vatandoost J, et al. Biotechnol Prog, 2012 Jan-Feb. PMID 22012919
  5. Targeted mutagenesis by homologous recombination in D. melanogaster. Rong YS, et al. Genes Dev, 2002 Jun 15. PMID 12080094, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-glutamyl carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-glutamyl carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gamma-glutamyl carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables vitamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in peptidyl-glutamic acid carboxylation IEA
Inferred from Electronic Annotation
more info
  
involved_in vitamin K metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-glutamyl carboxylase
Names
CG13927-PA
CG13927-PB
GC-PA
GC-PB
gamma-glutamyl-carboxylase
NP_001163323.1
NP_523885.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1623179..1629301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079161.4 → NP_523885.2  gamma-glutamyl carboxylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523885.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A089X5C5, Q9W0C4
    Related
    FBpp0072701
    Conserved Domains (3) summary
    smart00752
    Location:73 → 330
    HTTM; Horizontally Transferred TransMembrane Domain
    pfam05090
    Location:83 → 505
    VKG_Carbox; Vitamin K-dependent gamma-carboxylase
    cl21464
    Location:557 → 608
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_001169852.1 → NP_001163323.1  gamma-glutamyl carboxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163323.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A089X5C5, Q9W0C4
    Conserved Domains (3) summary
    smart00752
    Location:73 → 330
    HTTM; Horizontally Transferred TransMembrane Domain
    pfam05090
    Location:83 → 505
    VKG_Carbox; Vitamin K-dependent gamma-carboxylase
    cl21464
    Location:557 → 608
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NDA0 Q9NDA0
Q9W0C4 Q9W0C4

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