U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

alphaCOP Coat Protein (coatomer) alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38199, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
alphaCOPprovided by FlyBase
Official Full Name
Coat Protein (coatomer) alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0025725
Locus tag
Dmel_CG7961
See related
AllianceGenome:FB:FBgn0025725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alpha-COP; alphaCop; CG7961; Dmel\CG7961
Summary
Predicted to enable structural molecule activity. Involved in male meiosis cytokinesis; protein localization to cleavage furrow; and regulation of lipid storage. Located in endoplasmic reticulum-Golgi intermediate compartment. Part of COPI vesicle coat. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; male germline cell; and mesoderm. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See alphaCOP in Genome Data Viewer
Location:
62A9-62A9; 3-0.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1641066..1645199, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1641066..1645199, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Methyltransferase like 2 Neighboring gene Big brother Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Brother

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Engineered Flock House Virus for Targeted Gene Suppression Through RNAi in Fruit Flies (Drosophila melanogaster) in Vitro and in Vivo. Taning CNT, et al. Front Physiol, 2018. PMID 30018564, Free PMC Article
  2. COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. Frappaolo A, et al. J Cell Sci, 2017 Nov 1. PMID 28883096, Free PMC Article
  3. COPI-regulated mitochondria-ER contact site formation maintains axonal integrity. Maddison DC, et al. Cell Rep, 2023 Aug 29. PMID 37498742, Free PMC Article
  4. COPI activity coupled with fatty acid biosynthesis is required for viral replication. Cherry S, et al. PLoS Pathog, 2006 Oct. PMID 17040126, Free PMC Article
  5. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress. Zhang P, et al. Sci Rep, 2016 Feb 18. PMID 26887613, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiosis cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cleavage furrow IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COPI vesicle coat IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
coat protein (coatomer) alpha
Names
CG7961-PA
CG7961-PB
COPI alpha subunit
alpha-coatomer protein
alphaCOP-PA
alphaCOP-PB
coatomer I

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1641066..1645199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167908.3 → NP_728648.1  coat protein (coatomer) alpha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77285, Q9W0B8
    Related
    FBpp0072693
    Conserved Domains (5) summary
    COG2319
    Location:2 → 320
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:5 → 321
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04053
    Location:354 → 765
    Coatomer_WDAD; Coatomer WD associated region
    pfam06957
    Location:815 → 1228
    COPI_C; Coatomer (COPI) alpha subunit C-terminus
    sd00039
    Location:57 → 91
    7WD40; WD40 repeat [structural motif]

  2. NM_058047.5 → NP_477395.1  coat protein (coatomer) alpha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77285, Q9W0B8
    Related
    FBpp0072694
    Conserved Domains (5) summary
    COG2319
    Location:2 → 320
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:5 → 321
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04053
    Location:354 → 765
    Coatomer_WDAD; Coatomer WD associated region
    pfam06957
    Location:815 → 1228
    COPI_C; Coatomer (COPI) alpha subunit C-terminus
    sd00039
    Location:57 → 91
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77285 O77285
Q9W0B8 Q9W0B8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous