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CG7970 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38205, updated on 9-Dec-2024

Summary

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Official Symbol
CG7970provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035252
Locus tag
Dmel_CG7970
See related
AllianceGenome:FB:FBgn0035252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.268; Dmel\CG7970
Summary
Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in several structures, including adult head; adult heart; anterior endoderm; gut section; and mesoderm. Orthologous to human PXMP2 (peroxisomal membrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG7970 in Genome Data Viewer
Location:
62A10-62A10; 3-0.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1652750..1654238)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1653005..1654112)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45815 Neighboring gene uncharacterized protein Neighboring gene Brother Neighboring gene Vesicle trafficking 1 Neighboring gene Serine-arginine repetitive matrix 2/3/4 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L23A Neighboring gene U snoRNA host gene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila model of the neurological symptoms in Mpv17-related diseases. Kodani A, et al. Sci Rep, 2022 Dec 31. PMID 36587049, Free PMC Article
  2. Drosophila Mpv17 forms an ion channel and regulates energy metabolism. Corrà S, et al. iScience, 2023 Oct 20. PMID 37810222, Free PMC Article
  3. Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements. Clyne PJ, et al. Genetics, 2003 Nov. PMID 14668392, Free PMC Article
  4. Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Blard O, et al. Hum Mol Genet, 2007 Mar 1. PMID 17309878
  5. Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster. Parker GA, et al. G3 (Bethesda), 2020 Mar 5. PMID 31969430, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monoatomic ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7970-PA
CG7970-PB
CG7970-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1652750..1654238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316449.1 → NP_001303378.1  uncharacterized protein Dmel_CG7970, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WGR0
    Conserved Domains (1) summary
    pfam04117
    Location:178 → 238
    Mpv17_PMP22; Mpv17 / PMP22 family

  2. NM_001274343.1 → NP_001261272.1  uncharacterized protein Dmel_CG7970, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261272.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0B2
    Conserved Domains (1) summary
    pfam04117
    Location:114 → 174
    Mpv17_PMP22; Mpv17 / PMP22 family

  3. NM_139384.3 → NP_647641.1  uncharacterized protein Dmel_CG7970, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647641.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0B2
    Related
    FBpp0072645
    Conserved Domains (1) summary
    pfam04117
    Location:114 → 174
    Mpv17_PMP22; Mpv17 / PMP22 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WGR0 A0A0S0WGR0
Q9W0B2 Q9W0B2

Gene LinkOut

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