U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mv mauve [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38259, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
mvprovided by FlyBase
Official Full Name
mauveprovided by FlyBase
Primary source
FLYBASE:FBgn0288310
Locus tag
Dmel_CG42863
See related
AllianceGenome:FB:FBgn0288310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11814; CG42863; CG5691; Dmel\CG42863; fs(3)ros; ros
Old locus tag
Dmel_CG11814; Dmel_CG5691
Summary
Involved in negative regulation of autophagosome size; phagocytosis; and regulation of organelle organization. Located in spindle pole and vesicle. Is expressed in adult head and organism. Used to study Chediak-Higashi syndrome. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
62B11-62B12; 3-1.0 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1950306..1964178, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1950306..1964178, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Microfibril-associated protein 1 Neighboring gene mutator 2 Neighboring gene Centrobin Neighboring gene antisense RNA:CR45827 Neighboring gene antisense RNA:CR45828 Neighboring gene Succinyl-CoA:3-ketoacid CoA transferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila embryos spatially sort their nutrient stores to facilitate their utilization. Kilwein MD, et al. Development, 2023 Oct 15. PMID 36805634, Free PMC Article
  2. Serine protease MP2 activates prophenoloxidase in the melanization immune response of Drosophila melanogaster. An C, et al. PLoS One, 2013. PMID 24260243, Free PMC Article
  3. Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster. Kasravi A, et al. Genetics, 1999 Jul. PMID 10388821, Free PMC Article
  4. Drosophila mauve mutants reveal a role of LYST homologs late in the maturation of phagosomes and autophagosomes. Rahman M, et al. Traffic, 2012 Dec. PMID 22934826, Free PMC Article
  5. Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins. Lattao R, et al. Dev Cell, 2021 Apr 5. PMID 33725482, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.
    Title: Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of autophagosome size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mauve
Names
CG42863-PB
mv-PB
rosario

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1950306..1964178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139424.2 → NP_647681.2  mauve [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647681.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W060
    Conserved Domains (3) summary
    smart01026
    Location:2796 → 3080
    Beach; Beige/BEACH domain
    cl17171
    Location:2704 → 2785
    PH-like; Pleckstrin homology-like domain
    cl29593
    Location:3308 → 3507
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W060.2 Q9W060

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools